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Table 3 Comparison of results of Southern Ethiopia and Kathmandu, Nepal studies

From: Evaluation of SD Bioline HIV/syphilis Duo rapid test kits in Nepal

RDT

Southern Ethiopia, 2014a

Kathmandu, Nepal, 2014b

SD HIV/syphilis Duo

Infection

 

% Sensitivity 95 % CI

HIV 100 (98.5 to 100)

100 % (95 % CI: 83.18–100 %)

Syphilis 97.6 (92.4 to 99.6)

95.45 (95 % CI: 84.86–98.74 %)

% Specificity % CI

HIV 99.5 (97.6 to 100)

100 % (95 % CI: 99.96–100 %)

Syphilis 96 (90.6 to 98.7)

99.87 (95 % CI: 99.78–99.92 %)

% PPV 95 % CI

HIV 99.5 (97.6 to 100)

100 % (95 % CI: 83.18–100 %)

Syphilis 95.4 (89.3 to 98.5)

76.36 (95 % CI: 63.65–85.63 %)

% NPV 95 % CI

HIV 100 (98.5 to 100)

100 % (95 % CI: 99.96–100 %)

Syphilis 98 (93.4 to 99.7)

99.89 (95 % CI; 99.39–99.99 %)

  1. aSyphilis reference method, TPHA; HIV reference method, KHB/STAT-PAK/Unigold algorithm + ELISA. KHB, Shenghai Kehua Bioengineering; NPV, negative predictive value; PPV, positive predictive value; RDT, rapid diagnostic test. Ref: [11]
  2. bReference method: Tested by using national HIV testing algorithm [7] with a combination of Determine HIV-1/2/O assay (Abbott Laboratories, Abbott Park, IL), Uni-Gold Recombinant HIV-1/2 (Trinity Biotech, Bray, Ireland) HIV 1/2 Stat-Pak Ultra Fast (Chembio Diagnostic Systems, Medford, NY). Testing for syphilis was done, first by RPR test by using IMMUTREP RPR test kit (Omega Diagnostics Scotland UK)