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Table 1 General characteristics of the reviewed studies and the primary results

From: Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis

     Age (years)b CD4+ counts (cells/μL)c   Assay resultse
Investigators Year Country ATB/non-ATB patients enrolleda ATB patients Non-ATB patients ATB patients Non-ATB patients IGRA methodd TP FP FN TN I
Aichelburg 2009 Austria 8/822 39 (32–47) 39 (32–47) 393 (264–566) 393 (264–566) QFT-IT 7 37 1 738 47
Davarpanah 2009 Iran 11/165 38 (23–60) 38 (23–60) 360 (34–1300) 360 (34–1300) QFT-IT 4 45 7 107 13
Veldsman 2009 South Africa 30/30 NR NR NR NR QFT-IT 9 11 15 16 9
Cattamanchi 2010 Uganda 112/100 33 (27–40) 33 (27–40) 49 (16–160) 49 (16–160) T-SPOT 61 34 23 40 54
Legesse 2010 Ethiopia 6/21 34.2 (18–70) 34.2 (18–70) NR NR QFT-IT 5 10 1 10 1
Leidl 2010 Uganda 19/109 33.4 ± 6 34.1 ± 8.3 182 (118) 283 (226) T-SPOT 17 59 0 46 6
         QFT-IT 13 74 6 31 4
Tan 2010 Taiwan 9/30 39.6 (30–52) 39.1 (19–67) 112 (31–332) 145 (0–596) T-SPOT 8 2 1 28 0
Bua 2011 Italy 9/64 41 (21–63) 41 (21–63) 270 (4–897) 270 (4–897) QFT-IT 2 6 6 47 12
Rangaka 2011 South Africa 50/729 35 (31–40) 36 (31–42) 169 (98–239) 198 (136–315) QFT-IT 32 298 15 383 51
Lagrange 2013 India 38/54 38.0 (30.5-42.0) 38.0 (30.5-42.0) NR NR QFT-IT 26 19 3 29 15
Markova 2014 Bulgaria 13/52 43 (29 – 63) 37 (21–66) 195 (15–450) 248 (36–785) T-SPOT 8 0 1 48 8
         QFT-IT 12 0 1 49 3
  1. aAll patients in the study were HIV-seropositive. ATB, active tuberculosis
  2. bThe values represent the means ± SD or medians with corresponding interquartile ranges (IQRs). NR, not reported in the study
  3. cThe values represent the means ± SD or medians with corresponding IQRs
  4. dIGRA, interferon gamma release assay. QFT-IT, QuantiFERON-TB Gold In-Tube assay. T-SPOT, T-SPOT.TB assay
  5. eTP true positive, FP false positive, FN false negative, TN true negative, I indeterminate