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Table 2 Characteristics of HCV positive and negative individuals, BC-HTC, Canada, 1990-2013

From: Twin epidemics of new and prevalent hepatitis C infections in Canada: BC Hepatitis Testers Cohort

 

HCV + ve group

HCV -ve group

 

M24 Seroa

>M24 Serob

Prevalent HCV

All Positives

All Negatives

 

N = 3628

N = 3436

N = 48717

N = 55781

N = 988381

 

N (%)

N (%)

N (%)

N (%)

N (%)

Age at baselinec

     

  < 15

17 (0.5)

1 (0.0)

420 (0.9)

438 (0.8)

20289 (2.1)

 15-24

962 (26.5)

410 (11.9)

2410 (5.0)

3782 (6.8)

145326 (14.7)

 25-34

1477 (40.7)

1234 (35.9)

9907 (20.3)

12618 (22.6)

259347 (26.2)

 35-44

827 (22.8)

1106 (32.2)

16534 (33.9)

18467 (33.1)

220626 (22.3)

 45-54

275 (7.6)

522 (15.2)

13068 (26.8)

13865 (24.9)

163134 (16.5)

  ≥ 55

70 (1.9)

163 (4.7)

6378 (13.1)

6611 (11.9)

179659 (18.2)

Median [IQR]

30 [24-37]

35 [28-43]

42 [34-49]

41 [33-48]

37 [28-50]

Age at 1st test

     

  < 15

100 (2.8)

84 (2.4)

421 (0.9)

605 (1.1)

25860 (2.6)

 15-24

1485 (40.9)

1128 (32.8)

2422 (5.0)

5035 (9.0)

189747 (19.2)

 25-34

1225 (33.8)

1278 (37.2)

9927 (20.4)

12430 (22.3)

261056 (26.4)

 35-44

605 (16.7)

712 (20.7)

16590 (34.1)

17907 (32.1)

208398 (21.1)

 45-54

169 (4.7)

195 (5.7)

13063 (26.8)

13427 (24.1)

147688 (14.9)

  ≥ 55

44 (1.2)

39 (1.1)

6294 (12.9)

6377 (11.4)

155632 (15.8)

Median [IQR]

26 [20-34]

28 [22-35]

42 [34-49]

40 [32-48]

35 [26-48]

Birth year

     

  < 1945

31 (0.9)

35 (1.0)

3102 (6.4)

3168 (5.7)

95848 (9.7)

 1945-1964

776 (21.4)

1037 (30.2)

32133 (66.0)

33946 (60.9)

310845 (31.5)

 1965-1974

1176 (32.4)

1214 (35.3)

9493 (19.5)

11883 (21.3)

209956 (21.2)

  ≥ 1975

1645 (45.3)

1150 (33.5)

3989 (8.2)

6784 (12.2)

371732 (37.6)

Sex

     

 Female

1728 (47.6)

1380 (40.2)

16741 (34.4)

19849 (35.6)

551952 (55.8)

 Male

1900 (52.4)

2056 (59.8)

31970 (65.6)

35926 (64.4)

436287 (44.1)

 Unknown

0 (0.0)

0 (0.0)

6 (0.0)

6 (0.0)

142 (0.0)

Year of diagnosis

     

 1990-1994

85 (2.3)

4 (0.1)

3978 (8.2)

4067 (7.3)

3913 (0.4)

 1995-1999

726 (20.0)

353 (10.3)

17936 (36.8)

19015 (34.1)

104863 (10.6)

 2000-2004

1177 (32.4)

939 (27.3)

11733 (24.1)

13849 (24.8)

172888 (17.5)

 2005-2009

994 (27.4)

1280 (37.3)

9130 (18.7)

11404 (20.4)

272886 (27.6)

 2010-2013

646 (17.8)

860 (25.0)

5940 (12.2)

7446 (13.4)

433831 (43.9)

HIV/AIDS at baseline

     

 Unknown

3450 (95.1)

3207 (93.3)

47568 (97.6)

54225 (97.2)

984182 (99.6)

 Yes

178 (4.9)

229 (6.7)

1149 (2.4)

1556 (2.8)

4199 (0.4)

HIV/AIDS (ever)

     

 Unknown

3264 (90.0)

3104 (90.3)

46257 (95.0)

52625 (94.3)

983694 (99.5)

 Yes

364 (10.0)

332 (9.7)

2460 (5.0)

3156 (5.7)

4687 (0.5)

HBV at baseline

     

 No/Unknown

3528 (97.2)

3349 (97.5)

48197 (98.9)

55074 (98.7)

974223 (98.6)

 Yes

100 (2.8)

87 (2.5)

520 (1.1)

707 (1.3)

14158 (1.4)

HBV (ever)

     

 No/Unknown

3453 (95.2)

3326 (96.8)

46927 (96.3)

53706 (96.3)

968459 (98.0)

 Yes

175 (4.8)

110 (3.2)

1790 (3.7)

2075 (3.7)

19922 (2.0)

Active TB at baseline

     

 No/Unknown

3621 (99.8)

3428 (99.8)

48634 (99.8)

55683 (99.8)

986909 (99.9)

 Yes

7 (0.2)

8 (0.2)

83 (0.2)

98 (0.2)

1472 (0.1)

Active TB (ever)

     

 No/Unknown

3611 (99.5)

3415 (99.4)

48466 (99.5)

55492 (99.5)

986473 (99.8)

 Yes

17 (0.5)

21 (0.6)

251 (0.5)

289 (0.5)

1908 (0.2)

Material deprivation quintile at baseline

     

 Unknown

96 (2.7)

79 (2.3)

2316 (4.8)

2491 (4.5)

14773 (1.5)

 Q1 (most privileged)

452 (12.5)

444 (12.9)

6247 (12.8)

7143 (12.8)

214007 (21.7)

 Q2

526 (14.5)

463 (13.5)

7500 (15.4)

8489 (15.2)

187587 (19)

 Q3

531 (14.6)

585 (17.0)

8522 (17.5)

9638 (17.3)

192265 (19.5)

 Q4

876 (24.2)

774 (22.5)

10580 (21.7)

12230 (21.9)

197116 (19.9)

 Q5 (most deprived)

1147 (31.6)

1091 (31.8)

13552 (27.8)

15790 (28.3)

182633 (18.5)

Social deprivation quintile at baseline

     

 Unknown

96 (2.7)

79 (2.3)

2316 (4.8)

2491 (4.5)

14773 (1.5)

 Q1 (most privileged)

271 (7.5)

283 (8.2)

5302 (10.9)

5856 (10.5)

180214 (18.2)

 Q2

349 (9.6)

337 (9.8)

6194 (12.7)

6880 (12.3)

175098 (17.7)

 Q3

540 (14.9)

463 (13.5)

8094 (16.6)

9097 (16.3)

175715 (17.8)

 Q4

703 (19.4)

720 (21.0)

9972 (20.5)

11395 (20.4)

201551 (20.4)

 Q5 (most deprived)

1669 (46.0)

1554 (45.2)

16839 (34.6)

20062 (36)

241030 (24.4)

Mental health at baselined

     

 No/Unknown

2199 (64.5)

2096 (65.0)

40934 (86.7)

45229 (84.0)

729398 (88.0)

 Yes

1209 (35.5)

1130 (35.0)

6297 (13.3)

8636 (16.0)

99054 (12.0)

Mental health 3yrs pre-baselined

     

 No/Unknown

2590 (76.0)

2653 (82.2)

43518 (92.1)

48761 (90.5)

781042 (94.3)

 Yes

818 (24.0)

573 (17.8)

3713 (7.9)

5104 (9.5)

47410 (5.7)

Illicit drug use at baselined

     

 No/Unknown

910 (26.7)

942 (29.2)

33036 (69.9)

34888 (64.8)

770499 (93.0)

 Yes

2498 (73.3)

2284 (70.8)

14195 (30.1)

18977 (35.2)

57953 (7.0)

Illicit drug use 3yrs pre-baselined

     

 No/Unknown

1084 (31.8)

1433 (44.4)

36193 (76.6)

38710 (71.9)

795325 (96.0)

 Yes

2324 (68.2)

1793 (55.6)

11038 (23.4)

15155 (28.1)

33127 (4.0)

Problematic alcohol use at baselined

     

 No/Unknown

2083 (61.1)

1896 (58.8)

38178 (80.8)

42157 (78.3)

777271 (93.8)

 Yes

1325 (38.9)

1330 (41.2)

9053 (19.2)

11708 (21.7)

51181 (6.2)

Problematic alcohol use 3yrs pre-baselined

     

 No/Unknown

2521 (74.0)

2555 (79.2)

41709 (88.3)

46785 (86.9)

802492 (96.9)

 Yes

887 (26.0)

671 (20.8)

5522 (11.7)

7080 (13.1)

25960 (3.1)

  1. a24-month Sero: Individuals who seroconverted within 24 months of the last negative test
  2. bIndividuals who seroconverted after 24 months of the last negative test
  3. cBaseline is defined as date of diagnosis (i.e. first HCV positive test or case report) for HCV positive individuals, and date of last negative test result for HCV negative individuals
  4. dMental health, drug misuse, alcohol misuse data was available up to 2012