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Table 4 Meta-analysis of the per lesion efficacy of cryotherapy compared to pentavalent antimonials

From: Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials

Per lesion efficacy N = 584 Study RR (95 % CI) % Weight
Fixed Random
Gurei M [22] 0.85 (0.73 – 0.99) 48.5 36.2
Özgóztaslis O [19] 1.33 (1.05 – 1.69) 19.5 30.0
Asilian A [21] 1.03 (0.85 – 1.23) 32.0 33.8
Overall Fixed effects 0.99 (0.89 – 1.10)   
Overall Random effects 1.04 (0.81 – 1.32)   
Sensitivity analysis Omitted study   Relative change
Gurei M [22] N = 133 1.16 (0.90 – 1.50) 11.45
Özgóztaslis O [19] N = 90 0.93 (0.77 – 1.11) −10.62
Asilian A [21] N = 361 1.06 (0.68 – 1.64) 1.70
Heterogeneity   
Dersimonian and Laird's, Q statistic (Chi-squared) 10.06 p-value = 0.006  
RI Coefficient (Proportion of total variance due to the between-study variance) 0.648  
Variance between studies 0,036  
Variance within studies 0,008  
Variation coeff. between studies 15,961  
No publication bias   
Begg’s test, Z Statistic 1.044, p = 0.296