Table 4 Meta-analysis of the per lesion efficacy of cryotherapy compared to pentavalent antimonials
Per lesion efficacy N = 584 Study | RR (95 % CI) | % Weight | |
|---|---|---|---|
Fixed | Random | ||
Gurei M [22] | 0.85 (0.73 – 0.99) | 48.5 | 36.2 |
Özgóztaslis O [19] | 1.33 (1.05 – 1.69) | 19.5 | 30.0 |
Asilian A [21] | 1.03 (0.85 – 1.23) | 32.0 | 33.8 |
Overall Fixed effects | 0.99 (0.89 – 1.10) | ||
Overall Random effects | 1.04 (0.81 – 1.32) | ||
Sensitivity analysis Omitted study | Relative change | ||
Gurei M [22] N = 133 | 1.16 (0.90 – 1.50) | 11.45 | |
Özgóztaslis O [19] N = 90 | 0.93 (0.77 – 1.11) | −10.62 | |
Asilian A [21] N = 361 | 1.06 (0.68 – 1.64) | 1.70 | |
Heterogeneity | |||
Dersimonian and Laird's, Q statistic (Chi-squared) | 10.06 p-value = 0.006 | ||
RI Coefficient (Proportion of total variance due to the between-study variance) | 0.648 | ||
Variance between studies | 0,036 | ||
Variance within studies | 0,008 | ||
Variation coeff. between studies | 15,961 | ||
No publication bias | |||
Begg’s test, Z Statistic | 1.044, p = 0.296 | ||