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Table 3 Efficacy (proportion of patients cured) in the study groups

From: Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials

Per lesion Cryotherapy N = 327 (Protocol) Control N = 257 (Protocol)
Özgöztaslis O [19] 93 (53/57) 69.7 (23/33)a
Gurei M [22] 78 (47/60) 92 (67/73)b
Asilian A [21] 57.2 (120/210) 55.6 (84/151)a
Overall (95 % CI) 67.3 (62.0 – 72.5) 67.7 (61.8 – 73.6)
Per patient Per Protocol N = 231 Intent to treat N = 271 Per Protocol N = 182 Intent to treat N = 199
Salmanpour R [13] 67.8 (14/20) 75 (15/20)a
Layegh P [10] 58.3 (21/36) 52.5 (21/40) 27.8 (10/36)a 25.6 (10/39)a
López P [20] 37.9 (25/66) 28.4 (25/88) 94.8 (73/77)a 81.1 (73/90) a
Negera E [14] 93.3 (83/89) 80.6 (83/103) 89.5 (17/19)b 85.0 (17/20)b
Soto J [13] 20 (4/20) 70 (21/30)a
Overall % (95 % CI) 63.6 (57.2 – 70.1) 54.2 (48.0 – 60.4) 74.7 (68.1 – 81.3) 68.3 (61.6 – 75.1)
  1. aIntralesional meglumine antimonial (Glucantime® or generic)
  2. bSodium stibogluconate (Pentostam® or generic)