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Table 2 Description of the studies included

From: Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials

Author

Year

Country

Population

Exclusion

Specie

Time

Özgöztaslis O [19]

1997

Turkey

Patients between 2–50 years seen in a medical center; mean of 12.

Sickness that is exacerbated by the cold, infected lesions and pregnant or nursing women

Leishmania spp.

6 months

Gurei M [22]

2000

Turkey

Patients with a confirmed parasitological diagnosis

N.E.

N.E

3 months

Asilian A [21]

2004

France

Patients from the Leishmania and Skin diseases Research Center. Age ranged 2–65 years, mean of 26.

Lesions > 2 months (to exclude any natural self-healing during follow-up), allergy to antimonials, those pregnant and breastfeeding

L. tropica/L. major

6 months

Salmanpour R [15]

2006

Iran

Patients attending the dermatological unit of the Faghihi Hospital, Shiraz

N.E.

Leishmania spp.

≥2 months

Layegh P [10]

2009

Iran

Patients ≤ 13 years from the Dermatological Clinic of the Qaem Hospital, Mashad. Age mean 6.8 ± 3.4 in cruytherapy and 6.2 ± 3.4 in Glucantime

Lesions ≥ 3 months, allergy to antimonials, patients who utilized another treatment at the beginning of the study

Leishmania spp.

6 months

López P [20]

2010

Colombia

Patients < 10 years from local hospitals in Santander and Tolima. 38.8 % women and 61.2 % men.

Use of anti-Leishmania drugs in the last 3 months, > 5 lesions, lesions on the border (<2 cm) of mucosal areas, eyes, nose, mouth or genitals

Leishmania (V.) panamensis

3 months

Negera E [14]

2012

Ethiopia

Patients from the Kibet Health Center. Age mean 18.4 ± 11.7 in cryotherapy and 19.6 ± 7.4 in SSG

N.E.

Leishmania aethiopica

6 months

Soto J [13]

2013

Bolivia

Patients > 12 years from the province of Chapare, Bolivia

Lesions > 30 mm, use of anti-Leishmania therapy in the last 3 months, history of concomitant diseases, mucosal lesions in the nose and mouth and immunosuppression

L. braziliensis

6 months

  1. N.E. The article does not give explicit information about this variable