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Table 2 Description of the studies included

From: Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials

Author Year Country Population Exclusion Specie Time
Özgöztaslis O [19] 1997 Turkey Patients between 2–50 years seen in a medical center; mean of 12. Sickness that is exacerbated by the cold, infected lesions and pregnant or nursing women Leishmania spp. 6 months
Gurei M [22] 2000 Turkey Patients with a confirmed parasitological diagnosis N.E. N.E 3 months
Asilian A [21] 2004 France Patients from the Leishmania and Skin diseases Research Center. Age ranged 2–65 years, mean of 26. Lesions > 2 months (to exclude any natural self-healing during follow-up), allergy to antimonials, those pregnant and breastfeeding L. tropica/L. major 6 months
Salmanpour R [15] 2006 Iran Patients attending the dermatological unit of the Faghihi Hospital, Shiraz N.E. Leishmania spp. ≥2 months
Layegh P [10] 2009 Iran Patients ≤ 13 years from the Dermatological Clinic of the Qaem Hospital, Mashad. Age mean 6.8 ± 3.4 in cruytherapy and 6.2 ± 3.4 in Glucantime Lesions ≥ 3 months, allergy to antimonials, patients who utilized another treatment at the beginning of the study Leishmania spp. 6 months
López P [20] 2010 Colombia Patients < 10 years from local hospitals in Santander and Tolima. 38.8 % women and 61.2 % men. Use of anti-Leishmania drugs in the last 3 months, > 5 lesions, lesions on the border (<2 cm) of mucosal areas, eyes, nose, mouth or genitals Leishmania (V.) panamensis 3 months
Negera E [14] 2012 Ethiopia Patients from the Kibet Health Center. Age mean 18.4 ± 11.7 in cryotherapy and 19.6 ± 7.4 in SSG N.E. Leishmania aethiopica 6 months
Soto J [13] 2013 Bolivia Patients > 12 years from the province of Chapare, Bolivia Lesions > 30 mm, use of anti-Leishmania therapy in the last 3 months, history of concomitant diseases, mucosal lesions in the nose and mouth and immunosuppression L. braziliensis 6 months
  1. N.E. The article does not give explicit information about this variable