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Table 1 Demographic and clinical characteristics of 345 patients with healthcare-associated methicillin-resistant Staphylococcus aureus bacteremia according to the appropriateness of initial empirical antimicrobial therapy

From: Effects of inappropriate empirical antibiotic therapy on mortality in patients with healthcare-associated methicillin-resistant Staphylococcus aureus bacteremia: a propensity-matched analysis

Variables All (n = 345) Appropriate (n = 154, 44.6 %) Inappropriate (n = 191, 55.4 %) Odds ratio (95 % confidence interval)
Male sex 154 (44.6) 97 (43.9) 124 (56.1) 0.92 (0.59–1.43)
Age (years), median (IQR) 67 (52–75) 66 (51–74) 67 (53–75) 0.99 (0.98–1.01)
Category of infection     
 Healthcare-associateda 51 (14.8) 29 (18.8) 22 (11.5) 1.78 (0.98–3.25)
 Nosocomial 294 (85.2) 125 (81.2) 169 (88.5)
Comorbidity     
 Malignancy 97 (28.1) 47 (30.5) 50 (26.2) 0.81 (0.50–1.29)
 Metabolic 122 (35.4) 52 (33.8) 70 (36.6) 1.14 (0.73–1.77)
 Trauma 29 (8.4) 10 (6.5) 19 (9.9) 1.59 (0.72–3.53)
 Charlson’s comorbidity indexb, median (IQR) 2 (1–4) 2 (1–5) 2 (1–4) 1.09 (1.00–1.20)
Primary focus of HA-MRSAB
 CR-BSI 177 (51.3) 93 (60.4) 84 (44.0) 0.52 (0.34–0.79)
 Pneumonia 40 (11.6) 13 (8.4) 27 (14.1) 1.79 (0.89–3.59)
Clinical severity
 Development of severe sepsis or septic shock 99 (28.7) 50 (32.5) 49 (25.7) 0.72 (0.45–1.15)
 Pitt’s bacteremia score at onset of bacteremiac, median (IQR) 1 (0–2) 1 (0–3) 1 (0–2) 1.08 (0.96–1.21)
Predisposing factors     
 Surgical operation 84 (24.3) 29 (18.8) 55 (28.8) 1.74 (1.05–2.91)
 Foreign body retention 15 (4.3) 12 (7.8) 3 (1.6) 0.189 (0.05–0.69)
 Prior antibiotics use 219 (63.5) 99 (64.3) 120 (62.8) 0.94 (0.60–1.46)
 Vancomycin MIC, mg/L 1 (1–1.5) 1 (1–1.5) 1 (1–1.5) 1.57 (0.81–3.04)
Outcomes     
 In-hospital mortality 114 (33.0) 51 (33.1) 63 (33.0) 0.99 (0.63–1.56)
 MRSAB-related mortality 57 (16.5) 24 (15.6) 33 (17.3) 1.13 (0.64–2.01)
  1. IQR interquartile range, APACHE acute physiology and chronic health evaluation, CR-BSI catheter-related bloodstream infection, MIC minimum inhibitory concentration, MRSAB methicillin-resistant Staphylococcus aureus bacteremia
  2. aMRSAB diagnosed within 48 h of hospital admission was considered healthcare-associated infection, if the patient presented with any healthcare-associated factor in the preceding 3 months
  3. bCharlson’s comorbidity score was calculated at the onset of MRSA bacteremia infection
  4. cPitt’s bacteremia score and APACHE II scores were assessed at the onset of MRSA bacteremia