Table 4 Association of different anti-Tat antibody isotypes with CD4⁺ T cell count and viral load

Univariate

Multivariate

Covariate

Stratum

n

Mean CD4⁺ T cells count (cells/μL)

IRR

95 % conf.int.

p-value

IRR

95 % conf.int.

p-value

HIV infection (years)

>3

69

403

1

–

–

1

–

–

≤3

19

501

1.24

(0.98 to 1.58)

0.079

1.10

(0.86 to 1.41)

0.443

IgG

neg.

48

431

1

–

–

1

–

–

pos.

40

415

0.96

(0.76 to 1.22)

0.764

0.97

(0.77 to 1.21)

0.761

IgM

neg.

43

353

1

–

–

1

–

–

pos.

45

491

1.39

(1.10 to 1.76)

0.007

1.34

(1.05 to 1.71)

0.019

IgA

neg.

73

448

1

–

–

1

–

–

pos.

15

306

0.68

(0.51 to 0.91)

0.010

0.73

(0.55 to 0.95)

0.020

Univariate

Multivariate

Covariate

Stratum

n

Mean viral load (Log₁₀ copies/ml)

IRR

95 % conf.int.

p- value

IRR

95 % conf.int.

p-value

HIV infection (years)

>3

65

4.68

1

–

–

1

–

–

≤3

18

4.26

0.91

(0.79 to 1.05)

0.203

0.96

(0.83 to 1.10)

0.553

IgG

neg.

45

4.47

1

–

–

1

–

–

pos.

38

4.74

1.06

(0.96 to 1.16)

0.230

1.05

(0.96 to 1.15)

0.284

IgM

neg.

40

4.84

1

–

–

1

–

–

pos.

43

4.36

0.90

(0.82 to 0.99)

0.027

0.92

(0.85 to 0.99)

0.037

IgA

neg.

68

4.46

1

–

–

1

–

–

pos.

15

5.20

1.17

(1.08 to 1.26)

<0.001

1.13

(1.06 to 1.21)

<0.001