Plasma DCV PK parameter | Geometric mean (CV%) | Geometric least-squares mean ratio (90 % CI) | |
---|---|---|---|
DCV alone (treatment B) (N = 12) | DCV + DTG (treatment C) (N = 12) | DCV + DTG vs DCV alone | |
Cmax (μg/mL) | 1.19 (42.6) | 1.22 (42.2) | 1.03 (0.843–1.25) |
AUC0-τ (hr · μg/mL) | 11.4 (47.9) | 11.2 (41.6) | 0.978 (0.831–1.15) |
Cτ (μg/mL) | 0.166 (69.3) | 0.176 (53.8) | 1.06 (0.876–1.29) |
CL/F (L/hr) | 5.25 (47.9) | 5.36 (41.6) | 1.02 (0.868–1.203) |
t1/2 (hr) | 8.58 (23.2) | 8.42 (29.4) | 0.982 (0.814–1.18) |