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Table 5 HLA associations for cutaneous/muco-cutaneous leishmaniasis from case control studies conducted to-date

From: Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review

Study Location Type of leishmaniasis Sample size Associations for susceptibility Odds ratio (95 % confidence interval) or p value Associations for resistance Odds ratio (95 % confidence interval) or p value
Ribas-Silva et al. [16] 2013 Brazil Cutaneous 160 patients DRB1*13 1.66; (1.08–2.56) B*45 P = 0.01
270 controls
B*35 1.67 (1.08–2.29)
B*44 1.67 (1.05–2.64)
B*27 7.1111; (1.78–28.33)
B*49 6.4 (1.85–22.17)
B*52 12.61 (3.08–51.66)
A*02 B*44 DRB1*07 (haplotype) P = 0.024
A*24 B*35 DRB1*01 (haplotype) P = 0.024
Olivo-Diaz et al. [15] 2004 Mexico Cutaneous 65 patients DRB1*0407 2.92 (1.68–5.06) DPB1*0401 0.38 (0.21–0.67)
100 controls
DPA1*0401 10.07 (1.25–80.73) DR2 (DRB1*15 and DRB1*16) 0.14 (0.05–0.38)
DPB1*0101 5.99 (1.98–18.16)
DQA*03011 2.14 (1.34–3.40)
DRB1*0407-DQA1*03011-DQB1*0302 (haplotype) 2.26 (1.27–4.00)
DRB1*0407- DQA1*03011-DQB1*0301 (haplotype) 6.94 (0.82–58.36)
Samaranayake et al. [51] 2016 Sri Lanka Cutaneous 200 patients DRB1*15 p = 0.002, Pc = 0.01 A*68 P = 0.03; Pc = 0.31
200 controls
B*07 P = 0.007; Pc = 0.13; OR = 0.36 (0.17–0.77
DRB1*15-DQB1*06 (haplotype) P = 0.00; Pc < 0.01; OR = 0.3 (0.2–.0.6)
DRB1*07-DQB1*02 (haplotype) P = 0.03; Pc = 0.09
DRB1*04-DQB1*02 (haplotype) P = 0.03; Pc = 0.09
Lara et al. [13] 1991 Venezuela Cutaneous Family study of patients and unaffected family members (n-24 families) A*28 P = 0.0018 B*15 0.0062
Bw22 P = 0.012
DQB1*0302 P = 0.036
Bw22CF31 (haplotype) P = 0.0076
Bw22DR*11DQ*7 (haplotype) P = 0.0163
DQw3 Pc = 0.036
Petzl-Erler et al. [49] 1991 Brazil Muco-cutanous 43 patients DQB1*03 p = 0.006 DR2 (DRB1*15 and DRB1*16) p = 0.004
111 controls
el-Mogy et al. [50] 1993a Egypt Cutaneous 27 patients A*11 NA   
B*5 NA
B*7 NA
Barbier et al. [17] 1987 Asian refugees in French Guiana Cutaneous 32 cases    Cw7 p = 0.01
55 controls
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