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Table 2 HLA class I and class II allele distribution in patients with localised cutaneous leishmaniasis and population controls (n- 140 patients and 140 controls)

From: Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review

  Allele frequency    
Allele Patients Controls P value* Pc ** OR (95 % CI)
HLA-A a 2n = 18 2n = 62    
A a 02 0.4444 0.2581 0.13 0.29 2.3 (0.77–6.84)
A a 03 0.1667 0.0807 0.28 0.43 2.3 (0.49–10.64)
A a 11 0.0556 0.0161 0.39 0.44 3.6 (0.21–60.41)
A a 23 0.0556 0.0161 0.39 0.39 3.6 (0.21–60.41)
A a 24 0.1111 0.0484 0.33 0.43 2.46 (0.38–15.99)
A a 29 0.0000 0.1774 0.06 0.28 NAa
A a 31 0.0556 0.1774 0.2 0.36 0.3 (0.03–2.27)
A a 33 0.1111 0.0161 0.09 0.27 7.6 (0.65–89.5)
A a 68 0.0000 0.2097 0.03 0.31 NAa
HLA-B 2n = 60 2n = 62    
B a 07 0.25 0.4839 0.007 0.13 0.36 (0.17–0.77)
B a 08 0.0333 0.0161 0.62 0.73 2.1 (0.19–23.83)
B a 14 0.0167 0.0000 0.49 0.85 NA
B a 15 0.0833 0.0484 0.44 0.83 1.8 (0.41–7.84)
B a 25 0.0167 0.0000 0.49 0.78 NA
B a 27 0.0333 0.0323 0.97 1.02 1.03 (0.14–7.6)
B a 35 0.1167 0.0645 0.32 0.67 1.92 (0.53–6.92)
B a 37 0.0167 0.0000 0.49 0.72 NA
B a 38 0.0167 0.0645 0.18 1.16 0.25 (0.03–2.26)
B a 39 0.0333 0.0000 0.24 1.14 NA
B a 40 0.1167 0.0968 0.72 0.81 1.23 (0.39–3.91)
B a 42 0.0000 0.0484 0.24 0.81 NA
B a 44 0.1 0.0323 0.16 1.52 3.33 (0.64–17.22)
B a 51 0.0333 0.0807 0.26 0.62 0.39 (0.07–2.11)
B a 52 0.0333 0.0000 0.24 0.91 NA
B a 53 0.0167 0.0000 0.49 0.67 NA
B a 55 0.0167 0.0000 0.49 0.62 NA
B a 57 0.0333 0.0000 0.24 0.76 NA
B a 58 0.0333 0.0323 1.0 1.0 1.03 (0.14–7.59)
HLA-DRB1 2n = 34 2n = 88    
DRB1 a 03 0.0000 0.0114 1.0 1.17 NA
DRB1 a 04 0.0000 0.1023 0.06 0.21 NA
DRB1 a 07 0.0000 0.0682 0.18 0.43 NA
DRB1 a 09 0.0000 0.0227 1.0 1.75 NA
DRB1 a 14 0.0000 0.0227 1.0 1.4 NA
DRB1 a 15 1.0000 0.7614 0.002 0.01 NA
DRB1 a 16 0.0000 0.0114 1.0 1.0 NA
HLA-DQB1 2n = 358 2n = 346    
 DQB1a02 0.1229 0.159 0.11 0.28 0.71 (0.46–1.08)
 DQB1a03 0.2458 0.2139 0.2 0.34 1.25 (0.88–1.78)
 DQB1a04 0.0000 0.0116 0.06 0.29 NA
 DQB1a05 0.3045 0.3035 0.89 0.89 0.98 (0.71–1.35)
 DQB1a06 0.3268 0.3121 0.62 0.78 1.08 (0.79–1.49)
  1. 2n, where n is the number of individuals successfully genotyped at each locus
  2. * P value was calculated by Pearson’s chi-square test or Fisher’s exact test
  3. ** Pc, corrected P values for the number of alleles tested, calculated using the False Discovery Rate method
  4. ainterpretations cannot be made due to limited sample size