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Table 2 Nested case control analysis: characteristics of patients with cleared versus persistent bacteremia

From: Sending repeat cultures: is there a role in the management of bacteremic episodes? (SCRIBE study)

 

Cleared bacteremia (n = 118)

Persistent bacteremia (n = 118)

P

Male n (%)

70 (59.8)

80 (67.8)

0.18

Age(y) median (IQR)

66.5 (54–77)

68 (52–80)

0.61

Comorbidities n (%)

   

 Cardiac

41 (34.7)

45 (38.1)

0.59

 Respiratory

10 (8.5)

6 (5.1)

0.30

 Liver

7 (5.9)

3 (2.5)

0.22

 Diabetes

24 (20.3)

34 (28.8)

0.13

 Dialysis

8 (6.8)

13 (11.0)

0.25

 Solid tumor

33 (28.0)

24 (20.3)

0.17

 Hematologic malignancy

14 (11.9)

7 (5.9)

0.11

 Burn

6 (5.1)

6 (5.1)

1.0

 Polytrauma

13 (11.0)

11 (9.3)

0.67

 HIV

1 (0.9)

1 (0.9)

1.0

 Neutropenia

15 (12.7)

8 (6.8)

0.12

Length of stay(d) median(IQR)

24 (13–52)

25 (12–41)

0.44

Admitting service n(%)

   

 Medical

43 (36.4)

65 (55.1)

0.004

 Surgical

51 (43.2)

39 (33.1)

0.11

 Heme-Onc

24 (20.3)

14 (11.9)

0.71

ICU within 72 h of bacteremia n(%)

44 (37.3)

39 (33.1)

0.54

Hospital-acquired n (%)

58 (49.2)

55 (46.6)

0.70

Polymicrobial n(%)

21 (17.8)

9 (7.6)

0.019

Organism n(%)

   

 Total Gram-positive bacteria

77 (65.3)

90 (76.3)

0.044

S. aureus

26 (22.0)

53 (44.9)

<0.001

 Skin commensals

10 (8.5)

16 (13.6)

0.29

Enterococcus spp.

23 (19.5)

20 (16.9)

0.50

S. pneumoniae

5 (4.2)

0

0.03

 Viridans group streptococci

11 (9.3)

2 (1.7)

0.011

 β-hemolytic streptococci

5 (4.2)

0

0.03

S. anginosus group

3 (2.5)

1 (0.9)

0.31

 Other Gram-positive bacteria

6 (5.1)

1 (0.9)

0.062

 Total Gram-negative bacteria

44 (37.3)

27 (22.9)

0.016

E. coli

16 (13.6)

6 (5.1)

0.048

Klebsiella spp.

8 (6.8)

10 (8.5)

0.62

Pseudomonas spp.

6 (5.1)

5 (4.2)

0.76

 AmpC-producing bacteria

12 (10.2)

6 (5.1)

0.14

 Other Gram-negative bacteria

6 (5.1)

4 (3.4)

0.54

 Anaerobic bacteria

5 (4.2)

2 (1.7)

0.28

7-day mortality n(%)

5 (4.2)

13 (11.0)

0.05

30-day mortality n(%)

13 (11.0)

29 (24.6)

0.006

  1. NOTE: P values were calculated using the Chi square or Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables. P value threshold for significance was <0.05 (statistically significant values are bolded). IQR interquartile range, HIV human immunodeficiency virus, ICU intensive care unit, Heme-Onc hematology-oncology in-patient ward. Skin commensals include coagulase-negative staphylococci, Bacillus spp., Diphtheroids. AmpC-producers include Serratia marcescens, Providencia stuartii, Proteus vulgaris, Citrobacter spp., Enterobacter spp., Morganella morganii