High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates

Table 4 Sensitivity and specificity of HRM analysis in comparison with Drug susceptibility

Drug	Target	HRM profile		% variant	Drug susceptibility		% resistant	Sensitivity (%)	Specificity (%)
Drug	Target	+	−	% variant	+	−	% resistant	Sensitivity (%)	Specificity (%)
Rifampicin	rpoB	79	88	47.3	78	89	46.7	98.7 (92.2–99.9)	97.75 (91.2–99.6)
Isoniazid	katG and/or	77	90	46.1	78	89	46.7	98.7 (92.2–99.9)	100 (94.2–99.9)
Isoniazid	inhA promoter	77	90	46.1	78	89	46.7	98.7 (92.2–99.9)	100 (94.2–99.9)

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