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Table 3 Log-scale linear regression model of effect of disease parameters on baseline CRP in active Tuberculosis

From: Variation in C - reactive protein response according to host and mycobacterial characteristics in active tuberculosis

 

Fold-change in CRP, univariable analysis

Fold-change in CRP, multivariable analysis

TB culture result

Negative

0.52 (0.46–0.58)

p <0.001

0.55 (0.47–0.64)

p < 0.001

Positive

Reference

Ethnicity

White

0.97 (0.83–1.14)

p = 0.737

0.87 (0.81–1.04)

p = 0.139

Americas

1.37 (1.05–1.80)

p = 0.022

1.22 (0.89–1.67)

p = 0.213

Asian

0.51 (0.44–0.60)

p <0.001

0.49 (0.40–0.58)

p < 0.001

Eastern Mediterranean

1.04 (0.86–1.26)

p = 0.7

1.06 (0.85–1.31)

p = 0.570

Black

Reference

HIV status

Positive

1.77 (1.49–2.10)

p < 0.001

1.37 (1.13–1.67)

p = 0.001

Negative

Reference

Age

<16

0.48 (0.37–0.62)

p < 0.001

0.68 (0.46–0.99)

p = 0.044

16–35

0.94 (0.82–1.09)

p = 0.427

0.86 (0.70–1.03)

p = 0.104

35–50

1.08 (0.92–1.27)

p = 0.351

0.88 (0.72–1.08)

p = 0.223

<50

Reference

Site of disease

Pleural/pericardial

1.70 (1.40–2.06)

p < 0.001

1.49 (1.17–1.88)

p = 0.01

Abdominal

1.56 (1.19–2.06)

p = 0.001

1.77 (1.29–2.42)

p <0.001

Miliary/disseminated

1.46 (1.07–2.00)

p = 0.018

1.24 (0.86–1.79)

p = 0.243

Bone/joint

0.84 (0.68–1.04)

p = 0.111

0.92 (0.71–1.19)

p = 0.540

Peripheral lymph node

0.44 (0.38–0.52)

p < 0.001

0.52 (0.42–0.63)

p <0.001

Skin/soft tissue

0.29 (0.18–0.48)

p < 0.001

0.41 (0.23–0.70)

p = 0.001

CNS

0.41 (0.31–0.55)

p < 0.001

0.38 (0.28–0.53)

p < 0.001

Pulmonary

Reference

Gender

Male

1.40 (1.24–1.58)

p <0.001

1.29 (1.13–1.48)

p <0.001

Female

Reference