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Table 2 Factors associated with incident TB during follow up [15 TB cases among 634 participants in 565 person-years of follow up]

From: The incidence of tuberculosis among hiv-positive individuals with high CD4 counts: implications for policy

Variable

Category

TB cases

Person-years of follow up

Incidence per 100 person years (95 % CI)

Univariable analysis

Multivariable analysis

Unadjusted HR [95 % CI]

p-value

Adjusted HR [95 % CI]

p-value

 

Total population

15

565

2.7 (1.6–4.4)

    

Gender

Female

13

458

2.8 (1.6–4.9)

1

   

Male

2

107

1.9 (0.5–7.4)

0.66 (0.15–2.91)

0.560

Age

<35 years

6

258

2.3 (1.0–5.2)

1

   

≥35 years

9

307

2.9 (1.5–5.6)

1.27 (0.45–3)

0.649

Employed

No

11

338

3.3 (1.8–5.9)

1

   

Yes

4

227

1.8 (0.7–4.7)

0.53 (0.17–1.68)

0.264

Ever smoked

No

10

440

2.3 (1.2–4.2)

1

   

Yes

5

125

4.0 (1.7–9.6)

1.76 (0.60–5.14)

0.322

Currently drink alcohol

No

8

341

2.3 (1.2–4.7)

1

   

Yes

7

224

3.1 (1.5–6.5)

1.32 (0.48–3.64)

0.593

Duration since HIV test

≥ 2 years

6

193

3.1 (1.4–6.9)

1

0.905

  

<2 years

5

207

2.4 (1.0–5.8)

0.78 (0.24–2.57)

missing

4

164

2.4 (0.9–6.9)

0.79 (0.22–2.82)

On ART

No

7

209

3.4 (1.6–7.0)

1

 

1

 

Yes

8

356

2.2 (1.1–4.5)

0.65 (0.24–1.81)

0.461

0.68 (0.18–1.82)

0.458

Current or prior INH use

No

12

446

2.7 (1.5–4.7)

1

   

Yes

3

119

2.5 (0.8–7.8)

0.95 (0.27–3.36)

0.930

Current CPT use

No

12

464

2.5 (1.4–4.4)

1

   

Yes

3

81

3.7 (1.2–11.4)

1.48 (0.42–5.26)

0.557

Previous TB treatment

No

10

416

2.4 (1.3–4.5)

1

   

Yes

5

149

3.4 (1.4–8.1)

1.40 (0.48–4.10)

0.545

CD4 count

≥500 cells/μl

8

335

2.4 (1.2–4.8)

1

   

350–500 cells/μl

6

184

3.3 (1.5–7.3)

1.35 (0.47–3.89)

0.828

missing

1

47

2.1 (0.3–15.2)

0.86 (0.11–6.90)

BMI category

≥18.5 kg/m2

12

521

2.3 (1.3–4.1)

1

 

1

0.036

<18.5 kg/m2

3

32

9.4 (3.0–29.1)

3.93 (1.11–13.92)

0.034

3.87 (1.09–13.73)

missing

0

12

0

-

1