Variable | Category | TB cases | Person-years of follow up | Incidence per 100 person years (95 % CI) | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|---|---|---|---|
Unadjusted HR [95 % CI] | p-value | Adjusted HR [95 % CI] | p-value | |||||
Total population | 15 | 565 | 2.7 (1.6–4.4) | |||||
Gender | Female | 13 | 458 | 2.8 (1.6–4.9) | 1 | |||
Male | 2 | 107 | 1.9 (0.5–7.4) | 0.66 (0.15–2.91) | 0.560 | |||
Age | <35 years | 6 | 258 | 2.3 (1.0–5.2) | 1 | |||
≥35 years | 9 | 307 | 2.9 (1.5–5.6) | 1.27 (0.45–3) | 0.649 | |||
Employed | No | 11 | 338 | 3.3 (1.8–5.9) | 1 | |||
Yes | 4 | 227 | 1.8 (0.7–4.7) | 0.53 (0.17–1.68) | 0.264 | |||
Ever smoked | No | 10 | 440 | 2.3 (1.2–4.2) | 1 | |||
Yes | 5 | 125 | 4.0 (1.7–9.6) | 1.76 (0.60–5.14) | 0.322 | |||
Currently drink alcohol | No | 8 | 341 | 2.3 (1.2–4.7) | 1 | |||
Yes | 7 | 224 | 3.1 (1.5–6.5) | 1.32 (0.48–3.64) | 0.593 | |||
Duration since HIV test | ≥ 2 years | 6 | 193 | 3.1 (1.4–6.9) | 1 | 0.905 | ||
<2 years | 5 | 207 | 2.4 (1.0–5.8) | 0.78 (0.24–2.57) | ||||
missing | 4 | 164 | 2.4 (0.9–6.9) | 0.79 (0.22–2.82) | ||||
On ART | No | 7 | 209 | 3.4 (1.6–7.0) | 1 | 1 | ||
Yes | 8 | 356 | 2.2 (1.1–4.5) | 0.65 (0.24–1.81) | 0.461 | 0.68 (0.18–1.82) | 0.458 | |
Current or prior INH use | No | 12 | 446 | 2.7 (1.5–4.7) | 1 | |||
Yes | 3 | 119 | 2.5 (0.8–7.8) | 0.95 (0.27–3.36) | 0.930 | |||
Current CPT use | No | 12 | 464 | 2.5 (1.4–4.4) | 1 | |||
Yes | 3 | 81 | 3.7 (1.2–11.4) | 1.48 (0.42–5.26) | 0.557 | |||
Previous TB treatment | No | 10 | 416 | 2.4 (1.3–4.5) | 1 | |||
Yes | 5 | 149 | 3.4 (1.4–8.1) | 1.40 (0.48–4.10) | 0.545 | |||
CD4 count | ≥500 cells/μl | 8 | 335 | 2.4 (1.2–4.8) | 1 | |||
350–500 cells/μl | 6 | 184 | 3.3 (1.5–7.3) | 1.35 (0.47–3.89) | 0.828 | |||
missing | 1 | 47 | 2.1 (0.3–15.2) | 0.86 (0.11–6.90) | ||||
BMI category | ≥18.5 kg/m2 | 12 | 521 | 2.3 (1.3–4.1) | 1 | 1 | 0.036 | |
<18.5 kg/m2 | 3 | 32 | 9.4 (3.0–29.1) | 3.93 (1.11–13.92) | 0.034 | 3.87 (1.09–13.73) | ||
missing | 0 | 12 | 0 | - | 1 |