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Table 1 Summary of the 20 studies included in the review

From: The effect of surgery on the outcome of treatment for multidrug-resistant tuberculosis: a systematic review and meta-analysis

Author

Year of publication

Design

Sample size overall

Sample size surgery/non surgery

Country

% Male

Ageb

XDR

HIV

Dravniece [26]

2009

rc

254

77/177

Latvia

nr

nr

nr

nr

Gegia [35]

2012

pc

380

37/343

Georgia

nr

nr

13 %

1 %

Karagoz [34]

2009

rc

142

35/107

Turkey

100 %

39

nr

nr

Keshavjee [33]

2008

rc

608

56/552

Russia

83 %

~35

5 %

0.8 %

Kim [31]

2007

rc

211

63/148

South Korea

59 %

37

20 %

0 %

Kim [32]

2008

rc

1407

60/1347

South Korea

74 %

43

5 %

5 %

Kwak [30]

2015

rc

123

18/105

South Korea

56 %

37

21 %

0 %

Kwon [22]

2008

rc

155

35/120

South Korea

53 %

40

17 %

0 %

Leimane [23]

2005

rc

204

19/185

Latvia

77 %

43 (m); 39 (f)

nr

0.5 %

Mitnick [24]

2008

rc

48

7/41a

Peru

65 %

32

100 %

0 %

Shean [29]

2008

rc

491

28/463

South Africa

59 %

nr

nr

9 %

Sklyuev [27]

2013

pc

102

49/53

not described

nr

nr

nr

nr

Tahaoglu [28]

2001

rc

158

36/122

Turkey

87 %

42 (po); 36 (so)

0 %

0 %

Torun [25]

2007

rc

252

66/186

Turkey

81 %

38

nr

nr

Ahuja [36]

2012

ma

9153

499/8654

23 countries

69 %

39

0 %

14 %

Falzon [20]

2013

ma

6724

373/6351

Multiple countries

69 %

40

6 %

11 %

Fox [21]

unpublished

ma

  

Canada; USA; Taiwan; Korea; Japan; Estonia; UK; France

62 % (s);

70 % (ns)

37 (s); 39.4 (ns)

8.6 % (s);

5.1 % (ns)

nr

Johnston [37]

2009

ma

nr

nr

Canada

69 %

40

nr

nr

Kempker [9]

2012

sr

3218 (by calculation)

312/2906 (by calculation)

Korea, Turkey, Russia, Latvia, USA

nr

nr

nr

nr

Marrone [10]

2013

ma

5284

706/4578

Canada; USA; South Africa; Germany; Spain; Netherlands; South Korea; Turkey; Russia; Latvia; Peru; Argentina; Japan

70 %

40

Nr

nr

  1. rc retrospective cohort, pc prospective cohort, ma meta-analysis, sr systematic review (no meta-analysis), nr not reported, m male, f female, po poor outcome, so successful outcome, s surgery, ns non-surgery
  2. aXDR cohort only (MDR cohort has 603 patients [87 in the surgery arm and 516 in the non-surgery arm], outcomes not described)
  3. bEither mean or median, unless stated