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Table 1 ᅟ

From: Neonatal infections with multidrug-resistant ESBL-producing E. cloacae and K. pneumoniae in Neonatal Units of two different Hospitals in Antananarivo, Madagascar

 

Total n (%)

Befelatanana n (%)

Soavinandriana n (%)

p-value

Neonates

Number

303

164

139

 

Sex

 Male

 Female

    

172 (56.8)

90 (54.9)

82 (59.0)

 

131 (43.2)

74 (45.1)

57 (41.0)

0.54

Sex-ratio

1.3

1.2

1.4

0.54

Gestational age (weeks) [mean]

38 [24–43]

38 [24–43]

38 [26–42]

0.25

Birth weight (g)

[mean, 95%CI]

2663

[2576–2750]

2559

[2441–2677]

2785

[2658–2912]

0.01

Antimicrobial treatment

154 (50.8)

120 (73.2)

34 (24.5)

<0.01

Death

47 (15.5)

41 (25)

6 (4.3)

<0.01

Gastric samples

 Positive Gastric samples

 True Positives (contamination excluded)

 Bacteria

   Escherichia coli

   ESBLa-producer

   Enterobacter cloacae

   ESBL-producer

   Klebsiella pneumoniae

   ESBL-producer

   Group B Streptococcus

  Other organismsb

    

282 (93.1)

143 (87.2)

139 (100)

60 (21.3)

34 (23.8)

26 (18.7)

<0.01

72

39

33

 

32 (44.4)

0

15 (38.5)

0

17 (51.5)

0

0.68

11 (15.3)

7

7 (17.9)

5

4 (12.1)

2

 

6 (8.3)

5

4 (10.2)

3

2 (6.1)

2

 

4 (5.5)

2 (5.1)

2 (6)

 

19 (26.3)

11 (28.2)

8 (24.2)

 

Blood cultures

 Positive blood cultures

    

254 (83.8)

145 (88.4)

109 (78.4)

 True Positives (contamination excluded)

 Bacteria

76 (29.9)

62 (42.8)

14 (12.8)

<0.01

99

79

20

 

   Escherichia coli

   ESBL-producer

   Enterobacter cloacae

   ESBL-producer

   Klebsiella pneumonia

   ESBL-producer

   Acinetobacter baumannii

   Group B Streptococcus

   Enterococcus sp

  Other organismsc

7 (7.1)

0

4 (5.14)

0

3 (15)

0

 

28 (28.3)

28

27 (34.2)

27

1 (5)

1

<0.01

14 (14.1)

11

13 (16.4)

10

1 (5)

1

8 (8.1)

6 (7.6)

2 (10)

 

9 (9)

5 (6.3)

4 (20)

 

14 (14.1)

12 (15.1)

2 (10)

 

19 (19.1)

12 (19.2)

7 (35)

 

Mothers

Antibiotic before delivery

36 (11.9)

5 (3)

31 (22.3)

<0.01

Pregnancy monitoring

 Hospital

 Health center

 General practitioner

 Mid-wife

 No follow up

 

101 (33.3)

10 (6.1)

91 (65.5)

<0.01

97 (32)

69 (42.1)

28 (20.1)

 

35 (11.6)

25 (15.2)

10 (7.2)

0.33

38 (12.5)

33 (20.1)

5 (3.6)

 

22 (7.3)

20 (12.2)

2 (1.4)

<0.01

Intrapartum antibiotic

77 (25.4)

11 (6.7)

66 (47.5)

<0.01