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Table 1 ᅟ

From: Neonatal infections with multidrug-resistant ESBL-producing E. cloacae and K. pneumoniae in Neonatal Units of two different Hospitals in Antananarivo, Madagascar

  Total n (%) Befelatanana n (%) Soavinandriana n (%) p-value
Neonates
Number 303 164 139  
Sex
 Male
 Female
    
172 (56.8) 90 (54.9) 82 (59.0)  
131 (43.2) 74 (45.1) 57 (41.0) 0.54
Sex-ratio 1.3 1.2 1.4 0.54
Gestational age (weeks) [mean] 38 [24–43] 38 [24–43] 38 [26–42] 0.25
Birth weight (g)
[mean, 95%CI]
2663
[2576–2750]
2559
[2441–2677]
2785
[2658–2912]
0.01
Antimicrobial treatment 154 (50.8) 120 (73.2) 34 (24.5) <0.01
Death 47 (15.5) 41 (25) 6 (4.3) <0.01
Gastric samples
 Positive Gastric samples
 True Positives (contamination excluded)
 Bacteria
   Escherichia coli
   ESBLa-producer
   Enterobacter cloacae
   ESBL-producer
   Klebsiella pneumoniae
   ESBL-producer
   Group B Streptococcus
  Other organismsb
    
282 (93.1) 143 (87.2) 139 (100)
60 (21.3) 34 (23.8) 26 (18.7) <0.01
72 39 33  
32 (44.4)
0
15 (38.5)
0
17 (51.5)
0
0.68
11 (15.3)
7
7 (17.9)
5
4 (12.1)
2
 
6 (8.3)
5
4 (10.2)
3
2 (6.1)
2
 
4 (5.5) 2 (5.1) 2 (6)  
19 (26.3) 11 (28.2) 8 (24.2)  
Blood cultures
 Positive blood cultures
    
254 (83.8) 145 (88.4) 109 (78.4)
 True Positives (contamination excluded)
 Bacteria
76 (29.9) 62 (42.8) 14 (12.8) <0.01
99 79 20  
   Escherichia coli
   ESBL-producer
   Enterobacter cloacae
   ESBL-producer
   Klebsiella pneumonia
   ESBL-producer
   Acinetobacter baumannii
   Group B Streptococcus
   Enterococcus sp
  Other organismsc
7 (7.1)
0
4 (5.14)
0
3 (15)
0
 
28 (28.3)
28
27 (34.2)
27
1 (5)
1
<0.01
14 (14.1)
11
13 (16.4)
10
1 (5)
1
8 (8.1) 6 (7.6) 2 (10)  
9 (9) 5 (6.3) 4 (20)  
14 (14.1) 12 (15.1) 2 (10)  
19 (19.1) 12 (19.2) 7 (35)  
Mothers
Antibiotic before delivery 36 (11.9) 5 (3) 31 (22.3) <0.01
Pregnancy monitoring
 Hospital
 Health center
 General practitioner
 Mid-wife
 No follow up
 
101 (33.3) 10 (6.1) 91 (65.5) <0.01
97 (32) 69 (42.1) 28 (20.1)  
35 (11.6) 25 (15.2) 10 (7.2) 0.33
38 (12.5) 33 (20.1) 5 (3.6)  
22 (7.3) 20 (12.2) 2 (1.4) <0.01
Intrapartum antibiotic 77 (25.4) 11 (6.7) 66 (47.5) <0.01