HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection

Table 4 Unadjusted and adjusted models assessing the association of HIV co-infection with plasma eotaxin levels (log₁₀ pg/mL) in ATAHC

	Unadjusted model		Adjusted model^a
	Estimated mean difference^b (95 % CI)	P	Estimated mean difference^b (95 % CI)	P
HIV co-infection
Negative	Reference		Reference
Positive	0.17 (0.07, 0.28)	<0.001	0.12 (0.01, 0.24)	0.038
Age, 10 years	0.08 (0.03, 0.13)	0.001	0.06 (0.00, 0.12)	0.039
Symptomatic acute HCV
No	Reference
Yes	0.05 (−0.05, 0.16)	0.309
ALT level, log IU/L	0.03 (−0.07, 0.14)	0.534	−0.02 (−0.13, 0.09)	0.712
Estimated duration of infection
<26 weeks	Reference
≥26 weeks	−0.05 (−0.15, 0.06)	0.375
Interferon lambda rs12979860 genotype
TT/CT	Reference
CC	0.05 (−0.06, 0.15)	0.379
HCV RNA level
<400,000 IU/mL	Reference		Reference
≥400,000 IU/mL	0.01 (−0.10, 0.13)	0.791	−0.02 (−0.14, 0.09)	0.689
HCV genotype^c
Genotype 1	Reference
Genotype 3	−0.08 (−0.19, 0.04)	0.184
Other	0.02 (−0.19, 0.23)	0.860

^aAdjusted for variables associated with eotaxin levels in unadjusted analysis or HIV status (i.e. age, ALT levels, and HCV RNA levels) as well as assay run (n = 117, R ² = 0.15)
^b β coefficient
^cOverall P = 0.372

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