Parameters | Initial studya | Later studyb | |||||
---|---|---|---|---|---|---|---|
AA (n = 360) | AL (n = 132) | P value | AA (n = 29) | AL (n = 29) | DHP (n = 59) | P value | |
Age (year) | Â | Â | Â | Â | Â | Â | Â |
 Mean (95 % CI) | 7.1(6.8–7.5) | 6.1 (5.5–6.6) | 0.001 | 6.8 (5.3–8.3) | 7.5 (6.1–8.9) | 9.5 (8.4–10.5) | 0.01 |
 No <5 years (%) | 85 (24) | 50 (38) | 0.002 | 11 (38) | 10 (34) | 10 (17) | 0.06 |
Body temperature (°C) |  |  |  |  |  |  |  |
 Mean (95 % CI) | 38.3 (38.2–38.4) | 38.4 (38.2–38.6) | 0.37 | 38 (37.5–38.4) | 37.8 (37.2–38.3) | 37.7 (37.2–38.3) | 0.76 |
 No. ≥ 37.4 °C (%) | 283 (79) | 100 (76) | 0.58 | 15 (52) | 16 (55) | 32 (54) | 0.96 |
Haematocrit (%) | Â | Â | Â | Â | Â | Â | Â |
 Mean (95 % CI) | 32.3 (31.9–32.8) | 31.2 (30.5–32) | 0.02 | 30.3 (29.2–32.3) | 31.5 (29.7–33.2) | 33.4 (33.2–34.5) | 0.01 |
 No. < 30 % (%) | 78 (22) | 45 (34) | 0.01 | 11 (38) | 6 (21) | 11 (19) | 0.12 |
Parasitaemia (μL−1) |  |  |  |  |  |  |  |
 Geometric mean | 59,978 | 60,210 | 0.48 | 55,803 | 45,054 | 33,543 | 0.07 |
 Range | 1636–1,096,636 | 1657–900,532 |  | 2100–249,600 | 2220–454,875 | 2000–458,750 |  |
 No. > 100,000 μL−1 (%) | 107(30) | 43 (33) | 0.62 | 10 (34) | 8 (28) | 13 (22) | 0.46 |
 No. > 100,000 μL−1 (%) | 30 (8) | 13 (10) | 0.73 | 0 (0) | 3 (10) | 4 (7) | 0.68 |
No. with parasitaemia on day 1 (%) | 22 (6) | 23 (17) | 0.05 | 14 (48) | 15 (52) | 28 (47) | 0.93 |
Parasite positivity on day 3 (%) | 2 (0.6) | 1 (0.7) | 1.0 | 0 (0) | 0 (0) | 0 (0) | - |
PRRD1 | Â | Â | Â | Â | Â | Â | Â |
 Geometric mean | 3.3 × 104 | 1.6 × 104 | 0.27 | 2.4 × 103 | 1.3 × 103 | 1.9 × 104 | 0.84 |
 Range | 2.0 × 100-1.1 × 106 | 2.1 × 100-9.0 × 105 |  | 3.3 × 100-2.4 × 106 | 7.1 × 10−1-4.5 × 105 | 5.6 × 10−1-1.3 × 105 | |
PRRD2 | Â | Â | Â | Â | Â | Â | 0.08 |
 Geometric mean | 5.7 × 104 | 6.0 × 104 | 0.4 | 4.1 × 104 | 4.5 × 104 | 2.6 × 104 | |
 Range | 1.6 × 101-1.1 × 106 | 1.6 × 103-9.0 × 105 |  | 2.1 × 103-2.4 × 106 | 2.2 × 103-4.5 × 105 | 3.5 × 101-4.6 × 105 | |
Parasitological efficacy | Â | Â | Â | Â | Â | Â | Â |
 ACPR | 348 | 136 |  | 27 | 28 | 59 |  |
 LPF | 12 | 4 |  | 2 | 1 | 0 |  |
 LCF | 0 | 0 |  | 0 | 0 | 0 |  |
 ETF | 0 | 0 |  | 0 | 0 | 0 |  |
 Cure rate (%) | 98.7 | 97.1 | 1.0 | 93.1 | 95.8 | 100 | 1.0 |
Fever clearance time (day) | Â | Â | Â | Â | Â | Â | Â |
 Mean (95 % CI) | 1.1 (1–1.1) | 1.1 (1–1.2) | 0.28 | 1.1 (0.9–1.3) | 1.3 (1–1.5) | 1.1 (1–1.2) | 0.3 |
Parasite clearance time (day) | Â | Â | Â | Â | Â | Â | Â |
 Mean (95 % CI) | 1.1 (1.05–1.1) | 1.2 (1.1–1.3) | 0.004 | 1.6 (1.4–1.9) | 1.6 (1.4–1.8) | 1.5 (1.4–1.7) | 0.84 |
Anaemia recovery time (day) | Â | Â | Â | Â | Â | Â | Â |
 Mean (95 % CI) | 11.1 (9.5–12.7) | 9.4 (7.3–11.5) | 0.22 | 18.9 (13.1–24.7) | 22.8 (21–45) | 11.2 (5–17.4) | 0.09 |