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Table 6 Risk factors for unresolved late-appearing anaemia after 2 weeks of starting treatment of uncomplicated falciparum malaria with artemether-lumefantrine, artesunate-amodiaquine or dihydroartemisinin-piperaquine showing the crude and adjusted odds ratio (OR) and the 95 % confidence interval (CI)

From: Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria

Variable Total no. No. with late-appearing anaemia OR (95 % CI) P value AOR (95 % CI) P value
Gender       
 Male 47 16 1    
 Female 37 12 0.9(0.4–2.3) 1.00 - -
Age (years)       
  ≥ 3 65 20 1    
  < 3 19 8 1.6(0.6–4.7) 0.52 - -
Haematocrit at presentation (day 0)       
  ≥ 25 % 65 20 1    
  < 25 % 19 8 1.6(0.6–4.7) 0.52 - -
Parasitaemia (μL−1)       
  ≤ 50,000 34 13 1    
  > 50,000 50 15 0.7(0.3–1.7) 0.58   
Parasite reduction ratio on day 1       
  > 104 57 14 1   1  
  ≤ 104 27 14 3.3 (1.3–8.7) 0.026 2.9 (1. −8.5) 0.05
Fever clearance time       
  ≤ 1 day 75 25 1    
  > 1 day 9 3 1.0(0.2–4.3) 1.00   
Time of occurrence of late-appearing anaemia       
  ≤ 28 days 62 13 1   1  
  > 28 days 22 15 8.1(2.7–22.9) 0.0002 7.5(2.5–22.9) <0.0001