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Table 3 Clinical, parasitological and other characteristics, and temporal patterns of change in haematocrit in children who developed late-appearing anaemia 3–6 weeks after start of treatment

From: Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria

  aPattern 3 (n = 23) bPattern 4 (n = 35) cPattern 7 (n = 32) ALL (n = 84) P value
% of total 27 35 38 100  
Gender M/F 14/9 15/14 18/14 47/37 0.80
Age (year)      
 Mean (sd) 7.5(3.2) 6.1(3.3) 4.5(2.9) 5.9(3.4) 0.003
 Range 2–13 1–13 1.1–13 1–13 0.01
 No. <5 years (%) 5 (22) 10 (34) 19 (59) 34 (0.40)
Duration of illness (days)      
 Mean (sd) 2.4(1.1) 3.0(1.0) 2.9(1.2) 2.8(1.1) 0.22
 Range 1–5 1–5 1–7 1–7
Weight (kg)      
 Mean (sd) 19.2(5.9) 17.4(5.7) 13.5(4.8) 16.5(5.9) 0.001
 Range 9–35 7–29 6–27 6–35
Haematocrit (%)      
 Mean (sd) 33.6(2.2) 32(2.6) 24.8(3.1) 29.6(4.8) <0.0001
 Range 30–37 30–38 18–29 18–38
Temperature (°C)      
 Mean (sd) 37.9(1.2) 38.5(1.0) 38.3(1.3) 38.3(1.2) 0.22
 Range 35.3–40 36.2–40.6 35.9–40.5 35.3–40.6 0.11
 No. with temp. >37.4 °C (%) 16 (70) 26 (90) 22 (69) 64 (76)
Parasitaemia (μL−1)      
 Geometric Mean 61,756 35,466 77,324 53,464 0.049d
 Range 2880–281,538 1800–345,600 3625–467,681 1800–467,681 0.03
 No. with >100,000 μL−1(%) 4(17) 6(21) 15(47) 25(30)
FIH/1000 asexual parasite cpb      
 Median 0.015 0.06 0.011 0.023 0.004e
 Range 0.004–0.35 0.01–0.66 0.0009–0.36 0.0009–0.66
  1. sd standard deviation, FIH fall in haematocrit, cpb cleared from peripheral blood
  2. aHaematocrit ≥30 % at presentation followed by a fall to <30 % 3–6 after start of treatment [Pattern 3]
  3. bHaematocrit ≥30 % at presentation, followed by a fall to <30 % within a few days and recovery within 1 and/or 2 weeks, and subsequent fall to <30 % 3–6 weeks after start of treatment. [Pattern 4]
  4. cHaematocrit <30 % at presentation, followed recovery within 1 and/or 2 weeks, and subsequent fall to <30 % 3–6 weeks after start of treatment [Pattern 7]
  5. dComparison showed that geometric parasitaemia was similar in Patterns 3 and 7
  6. eComparison showed that median FIH/1000 asexual parasites cleared from peripheral blood was similar in Patterns 3 and 7