|
Characteristic
|
No with severe sepsis or septic shock
|
Severe sepsis or septic shock in category (%)
|
Age-, sex- and comorbiditya-adjusted
|
|---|
|
Odds ratio
|
95 % CI
|
p
|
Risk of severe sepsis or septic shock (%)
|
95 % CI
|
|---|
|
Age (years)
|
|
<70
|
73
|
36.5
|
1
|
Reference
| |
35.0
|
28.7–42.0
|
|
70–79
|
33
|
31.7
|
0.81
|
0.48–1.37
|
0.44
|
30.8
|
22.0–39.8
|
|
≥80
|
41
|
37.2
|
1.24
|
0.75–2.10
|
0.39
|
40.7
|
30.8–50.5
|
|
p for trend
| | | | |
0.49
| | |
|
Sex
|
|
Male
|
82
|
37.4
|
1
|
Reference
| |
37.6
|
31.2–44.0
|
|
Female
|
65
|
33.3
|
0.88
|
0.57–1.34
|
0.54
|
33.1
|
26.5–39.8
|
|
Charlson ComorbidityIndex (CCI)
|
|
0
|
46
|
31.9
|
1
|
Reference
| |
33.0
|
24.7–41.2
|
|
1–2
|
70
|
36.8
|
1.10
|
0.64–1.91
|
0.73
|
36.5
|
29.5–43.3
|
|
≥3
|
31
|
38.7
|
1.29
|
0.72–2.29
|
0.39
|
37.7
|
26.8–48.5
|
|
p for trend
| | | | |
0.37
| | |
|
Comorbiditiesa
|
|
Malignant disease
|
33
|
36.7
|
0.98
|
0.59–1.61
|
0.94
|
35.1
|
25.2–45.1
|
|
Renal failure
|
16
|
66.7
|
2.20
|
0.95–5.11
|
0.07
|
53.5
|
33.4–73.5
|
|
Diabetes mellitus
|
14
|
27,4
|
0.62
|
0.32–1.21
|
0.16
|
26..7
|
14.6–38.7
|
|
Hypertension
|
38
|
38.7
|
1.17
|
0.71–1.91
|
0.54
|
38.2
|
28.2–48.1
|
|
Coronary heart disease
|
37
|
30.3
|
0.66
|
0.38–1.15
|
0.14
|
28.3
|
18.4–38.2
|
|
Heart failure
|
23
|
57.5
|
2.82
|
1.39–5.74
|
0.004
|
58.1
|
42.0–74.1
|
|
Chronic pulmonary disease
|
39
|
40.6
|
1.34
|
0.83–2.15
|
0.23
|
40.7
|
30.8–50.5
|
|
Cerebral ischemic disease
|
12
|
30.0
|
0.69
|
0.33–1.43
|
0.32
|
28.3
|
14.4–42.2
|
|
Place of acquisition
|
|
Community acquired
|
112
|
34.7
|
1
|
Reference
| |
34.6
|
29.6–40.0
|
|
Health-care associated
|
25
|
34.2
|
0.95
|
0.54–1.68
|
0.87
|
33.6
|
23.0–45.7
|
|
Hospital acquired
|
10
|
55.6
|
2.37
|
0.88–6.39
|
0.09
|
55.7
|
32.5–76.6
|
|
Time periode
|
|
1993–2002
|
63
|
47.0
|
1
|
Reference
| |
47.3
|
38.9–55.7
|
|
2003–2011
|
84
|
30.0
|
0.47
|
0.30–0.72
|
0.01
|
29.9
|
24.5–35.2
|
-
aThe association of age, sex, CCI and individual underlying comorbidities with the risk of severe sepsis or septic shock are not adjusted for comorbidity
