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Table 4 Proportion of severe sepsis/septic shock according to prior patient characteristics and infection-related characteristics

From: Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study

Characteristic No with severe sepsis or septic shock Severe sepsis or septic shock in category (%) Age-, sex- and comorbiditya-adjusted
Odds ratio 95 % CI p Risk of severe sepsis or septic shock (%) 95 % CI
Age (years)
 <70 73 36.5 1 Reference   35.0 28.7–42.0
 70–79 33 31.7 0.81 0.48–1.37 0.44 30.8 22.0–39.8
 ≥80 41 37.2 1.24 0.75–2.10 0.39 40.7 30.8–50.5
 p for trend      0.49   
Sex
 Male 82 37.4 1 Reference   37.6 31.2–44.0
 Female 65 33.3 0.88 0.57–1.34 0.54 33.1 26.5–39.8
Charlson ComorbidityIndex (CCI)
 0 46 31.9 1 Reference   33.0 24.7–41.2
 1–2 70 36.8 1.10 0.64–1.91 0.73 36.5 29.5–43.3
 ≥3 31 38.7 1.29 0.72–2.29 0.39 37.7 26.8–48.5
 p for trend      0.37   
Comorbiditiesa
 Malignant disease 33 36.7 0.98 0.59–1.61 0.94 35.1 25.2–45.1
 Renal failure 16 66.7 2.20 0.95–5.11 0.07 53.5 33.4–73.5
 Diabetes mellitus 14 27,4 0.62 0.32–1.21 0.16 26..7 14.6–38.7
 Hypertension 38 38.7 1.17 0.71–1.91 0.54 38.2 28.2–48.1
 Coronary heart disease 37 30.3 0.66 0.38–1.15 0.14 28.3 18.4–38.2
 Heart failure 23 57.5 2.82 1.39–5.74 0.004 58.1 42.0–74.1
 Chronic pulmonary disease 39 40.6 1.34 0.83–2.15 0.23 40.7 30.8–50.5
 Cerebral ischemic disease 12 30.0 0.69 0.33–1.43 0.32 28.3 14.4–42.2
Place of acquisition
 Community acquired 112 34.7 1 Reference   34.6 29.6–40.0
 Health-care associated 25 34.2 0.95 0.54–1.68 0.87 33.6 23.0–45.7
 Hospital acquired 10 55.6 2.37 0.88–6.39 0.09 55.7 32.5–76.6
Time periode
 1993–2002 63 47.0 1 Reference   47.3 38.9–55.7
 2003–2011 84 30.0 0.47 0.30–0.72 0.01 29.9 24.5–35.2
  1. aThe association of age, sex, CCI and individual underlying comorbidities with the risk of severe sepsis or septic shock are not adjusted for comorbidity