Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study

Table 3 30 day all-cause mortality in relation to disease acquisition, severity, focus and time period

Characteristic	No. of deaths within 30 days	30-day mortality within category (%)	Age-, sex- and comorbidity-adjusted^a
Characteristic	No. of deaths within 30 days	30-day mortality within category (%)	Odds ratio	95 % CI	p	Mortality risk (%)	95 % CI
Place of acquisition
Community acquired	34	10.6	1	Reference		10.9	7.6–14.3
Health-care associated	12	17.0	1.58	0.65–3.20	0.35	14.7	6.9–22.4
Hospital acquired	5	27.8	3.13	0.92–10.43	0.07	25.2	6.7–43.9
Severity
Sepsis without organ failure	14	5.2	1	Reference		5.4	2.7–8.02
Severe sepsis	23	21.0	5.19	2.44–11.10	<0.001	20.2	13.5–27.4
Septic shock	14	37.8	13.58	5.32–34.60	<0.001	35.0	21.6–49.0
p for trend					<0.001
Pitt bacteremia score
0	12	9.5		Reference		9.4	4.5–14.3
1	7	5.4	0.47	0.17–1.28	0.14	4.9	1.4–8.3
2	8	11.1	1.45	0.53–3.94	0.47	12.7	4.9–20.5
≥3	24	28.2	5.10	2.12–11.65	<0.001	29.8	20.7–39.0
p for trend					<0.001
Time period
1993–2002	17	12.7	1	Reference		13.5	7.9–19.2
2003–2011	34	12.1	0.77	0.43–1.61	0.59	11.8	8.2–15.3
Time to antibiotics^b
<6 hours	33	14.1	1	Reference		11.9	8.5–15.3
>6 hours	18	11.5	1.17	0.58–2.34	0.65	13.2	8.1–18.4

^aAdjusted for Charlson Comorbidity Index: 0, 1–2 and ≥3 ^bAlso adjusted for severity

ISSN: 1471-2334