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Table 2 Sensitivity of the different diagnostic tools for NS1 detection in plasma, urine and saliva

From: Evaluation of the performances of six commercial kits designed for dengue NS1 and anti-dengue IgM, IgG and IgA detection in urine and saliva clinical specimens

  Total Primary infection Secondary infection
Plasma ELISA All samples 66 % (159/241) 95.7 % (66/69) 51.1 % (69/135)
   DAOF ≤ 3 94.4 % (67/71) 100 % (29/29) 88.6 % (31/35)
   DAOF 4–7 66.7 % (82/123) 93.9 % (31/33) 51.4 % (36/70)
   DAOF 8–12 21.3 % (10/47) 85.7 % (6/7) 6.7 % (2/30)
Urine ELISA All samples 14.3 % (63/440) 18.3 % (23/126) 8.1 % (20/246)
   DAOF ≤ 3 9.9 % (8/81) 15.6 % (5/32) 2.4 % (1/41)
   DAOF 4–7 19.2 % (52/271) 21.5 % (17/79) 12.3 % (19/154)
   DAOF 8–12 3.4 % (3/88) 6.7 % (1/15) 0 % (0/51)
Urine RDT All samples 15.5 % (68/440) 18.3 % (23/126) 10.6 % (26/246)
   DAOF ≤ 3 11.1 % (9/81) 15.6 % (5/32) 4.9 % (2/41)
   DAOF 4–7 21 % (57/271) 21.5 % (17/79) 15.6 % (24/154)
   DAOF 8–12 2.3 % (2/88) 6.7 % (1/15) 0 % (0/51)
Saliva ELISA All samples 24.7 % (72/291) 43.5 % (37/85) 15.5 % (27/174)
   DAOF ≤ 3 25.5 % (12/47) 41.2 % (7/17) 19.2 % (5/26)
   DAOF 4–7 29.9 % (55/184) 46.7 % (28/60) 19.4 % (21/108)
   DAOF 8–12 8.3 % (5/60) 25 % (2/8) 2.5 % (1/40)
Saliva RDT All samples 20.8 % (60/289) b 31 % (26/84) a 16.2 % (28/173) a
   DAOF ≤ 3 14.9 % (7/47) 23.5 % (4/17) 11.5 % (3/26)
   DAOF 4–7 25.7 % (47/183) a 33.9 % (20/59) a 19.4 % (21/108) a
   DAOF 8–12 10.2 % (6/59) a 25 % (2/8) 10.3 % (4/39) a
  1. The sensitivity of the different diagnostic tools for NS1 detection in plasma, urine and saliva of DENV-infected patients is presented according to the time of sampling after the onset of the fever and the immune status of the patients
  2. DAOF Day After Onset of Fever
  3. a One invalid result
  4. b Two invalid results