Table 2 Primary and secondary resistance mutations in the Integrase by Sanger population sequencing
Patient | Major resistance mutation | Accesory mutation | Polymorphism mutation |
|---|---|---|---|
1F | N155H | __ | C56S, E85EG, L101I, S119P, T122I, H171Q, K173EK |
1A | N155H | __ | C56S, L101I, S119P, T122I, H171Q |
2F | N155H | __ | M50I, L68R, V71I, L101I, S119P, H171Q |
2A | N155H | __ | M50I, V71I, P90PS, L101I, S119P |
3F | __ | L74I | E96D, K111T, K160KT |
3A | __ | L74I | E96D, K111T, G123RS |
4F | __ | G163GR | L101I, I113V, G134E, V150AV |
4A | __ | G163GR | M50IM, L101I, I113V, V150A |
5F | __ | L74IM | M50V, V72I, K103R, K111T, A124T |
5A | __ | L74I | M50V, V72I, K103R, K111T |
6F | N155H | T97A | D55Y, V72I, K111T, I113V, S119R, G123S, A124N, T125A |
6A | __ | __ | V72I, K111T, I113V, S119R, G123S, A124N, T125A |
6 UDS | N155H (9.77 %) | T97A (12.42 %) | V72I(37.44 %), Y99C(4.65 %), T122I(12.56 %), K156N(14.35 %), E157A(15.35 %), K111T(39.53 %), I113V(29.3 %), S119R(37.44 %), G123S(97.21 %), A124N(43.26 %), T125A(45.58 %) |
7F | N155H | V151I | I113V, S119P, T122I, A124N, C130Y |
7A | N155H | V151I | G52P, S119PR, T122I, I161X |