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Table 3 Ribosomal and tRNA associated genes down-regulated in M. tuberculosis exposed to PZA under fast growth

From: The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

Fold change from pre-PZA to early recovery phase (100 μgml−1 for 4 h)

Fold change from pre-PZA to late recovery phase (100 μgml−1 for 2 MGT)

Gene name

UniProt ID

Annotation

1.12

−2.03

tRNA-Glu

 

tRNA-Glu

−1.45

−2.07

Rv0704

P95052

50S ribosomal protein L2

−1.43

−2.10

Rv0723

P95071

50S ribosomal protein L15

−1.02

−2.11

tRNA-Thr

 

tRNA-Thr

−1.07

−2.20

tRNA-Lys

 

tRNA-Lys

−1.12

−2.26

tRNA-Arg

 

tRNA-Arg

−1.55

−2.31

Rv0703

P95051

50S ribosomal protein L23

−1.60

−2.33

Rv0700

P0A5X0

30S ribosomal protein S10

−1.51

−2.40

Rv0722

P66181

50S ribosomal protein L30

−1.14

−2.42

tRNA-Val

 

tRNA-Val

−1.79

−2.45

Rv0709

P95057

50S ribosomal protein L29

−1.90

−2.72

Rv0710

P95058

30S ribosomal protein S17

−1.10

−2.04

tRNA-Met

 

tRNA-Met

  1. Genes encoding tRNAs or ribosome component proteins that were down-regulated by at least two fold (with an ANOVA p –value of less than 0.05) in M. tuberculosis under fast growth in the early recovery phase (4 h after the addition of 100 μgml−1 PZA) and/or the late recovery phase (2 MGT after the addition of 100 μgml−1 PZA) compared to the pre-PZA phase