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Table 3 Ribosomal and tRNA associated genes down-regulated in M. tuberculosis exposed to PZA under fast growth

From: The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

Fold change from pre-PZA to early recovery phase (100 μgml−1 for 4 h) Fold change from pre-PZA to late recovery phase (100 μgml−1 for 2 MGT) Gene name UniProt ID Annotation
1.12 −2.03 tRNA-Glu   tRNA-Glu
−1.45 −2.07 Rv0704 P95052 50S ribosomal protein L2
−1.43 −2.10 Rv0723 P95071 50S ribosomal protein L15
−1.02 −2.11 tRNA-Thr   tRNA-Thr
−1.07 −2.20 tRNA-Lys   tRNA-Lys
−1.12 −2.26 tRNA-Arg   tRNA-Arg
−1.55 −2.31 Rv0703 P95051 50S ribosomal protein L23
−1.60 −2.33 Rv0700 P0A5X0 30S ribosomal protein S10
−1.51 −2.40 Rv0722 P66181 50S ribosomal protein L30
−1.14 −2.42 tRNA-Val   tRNA-Val
−1.79 −2.45 Rv0709 P95057 50S ribosomal protein L29
−1.90 −2.72 Rv0710 P95058 30S ribosomal protein S17
−1.10 −2.04 tRNA-Met   tRNA-Met
  1. Genes encoding tRNAs or ribosome component proteins that were down-regulated by at least two fold (with an ANOVA p –value of less than 0.05) in M. tuberculosis under fast growth in the early recovery phase (4 h after the addition of 100 μgml−1 PZA) and/or the late recovery phase (2 MGT after the addition of 100 μgml−1 PZA) compared to the pre-PZA phase