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Table 1 DAVID Functional annotation clustering of genes that were down-regulated in M. tuberculosis exposed to PZA under different growth rates in early and late recovery

From: The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

   Slow growth (69.3 h MGT) Fast growth (23.1 h MGT)
   Down-regulated in early recovery Down-regulated in late recovery Down-regulated in early recovery Down-regulated in late recovery
Annotation scheme Annotation Count Bonferroni corrected EASE-value Count Bonferroni corrected EASE-value Count Bonferroni corrected EASE-value Count Bonferroni corrected EASE-value
KEGG_PATHWAY ribosome 25 4.00E-24 28 1.70E-26 n/a n/a 7 4.20E-08
GOTERM_MF_FAT structural constituent of ribosome 25 1.60E-21 28 4.10E-25 n/a n/a 7 1.10E-08
SP_PIR_KEYWORDS ribonucleoprotein 25 3.60E-21 28 3.40E-24 n/a n/a 7 1.90E-06
GOTERM_MF_FAT rRNA-binding 21 1.00E-20 23 2.30E-23 n/a n/a 4 1.10E-03
SP_PIR_KEYWORDS rRNA-binding 21 7.80E-21 23 4.30E-23 n/a n/a 4 8.10E-03
SP_PIR_KEYWORDS ribosomal protein 25 3.50E-20 28 5.00E-23 n/a n/a 7 3.10E-06
GOTERM_MF_FAT structural molecule activity 25 5.50E-20 28 2.60E-23 n/a n/a 7 2.50E-08
GOTERM_CC_FAT ribosome 25 2.50E-19 28 1.30E-21 n/a n/a 7 9.80E-05
GOTERM_CC_FAT ribonucleoprotein complex 25 8.80E-19 28 5.60E-21 n/a n/a 7 1.30E-04
GOTERM_BP_FAT translation 29 1.10E-17 32 1.00E-19 n/a n/a 7 9.20E-06
SP_PIR_KEYWORDS RNA-binding 22 7.50E-16 25 1.50E-18 n/a n/a 4 4.50E-02
GOTERM_MF_FAT RNA binding 26 1.80E-14 27 1.80E-14 n/a n/a 5 1.50E-03
GOTERM_CC_FAT ribosomal subunit 10 8.60E-09 10 3.60E-08 n/a n/a 4 3.20E-03
  1. A corrected EASE-value of 0.01 and minimum gene number per category of five was used to perform functional annotation clustering on all down-regulated genes in the early recovery phase (4 h after the addition of 100 μgml−1 PZA) or the late recovery phase (2 MGT after the addition of 100 μgml−1 PZA) compared to the pre-PZA phase