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Table 1 CDI Episodes in 2009 according to the definition used to identify CDI

From: The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases

Definition Medicarea Lab/Rxa SIDa Premier NIS
Positive test + diagnosis + Rx N/A N/A 4,623 (72.8)
Diagnosis + Rx within 14 days after hospital discharge or during hospitalization 1,303 (23.4) 1,088 (65.5) 1,347 (21.2)
Diagnosis + Positive test during hospitalization N/A N/A 108 (1.7)
Primary diagnosis 994 (17.8) 194 (11.7) 20,894 (30.5) 13 (0.02) 110,553 (32.8)
Diagnosis on admission 338 (6.1) N/A N/A 2 (< 0.01) N/A
Positive test only N/A N/A N/A 205 (3.2) N/A
Secondary diagnosis 2,941 (52.7) 379 (22.8) 47,546 (69.5) 52 (0.08) 226,012 (67.2)
Total Inpatient CDI 5,576 1,661 68,440 6,350 336,565
Positive test + Diagnosis + Rx within +/−14 days of diagnosis or positive test date(s) N/A 87 (2.7)
Diagnosis on ≥ 2 service dates + Rx within +/−14 days of diagnosis date(s) 422 (10.4) 409 (12.6)
Positive test + diagnosis within +/−14 days N/A 6 (0.2)
Positive test + Rx within +/−14 days N/A 436 (13.4)
Diagnosis + Rx + lab test within +/−14 days of the diagnosis or lab test date(s) 133 (3.3) 148 (4.6)
Diagnosis + Rx within +/−14 days 334 (8.2) 524 (16.1)
Positive test only N/A 262 (8.1)
Diagnosis only 3,162 (77.6) 1,251 (38.5)
CDI test + Rx 25 (0.6) 129 (4.0)
Total Outpatient CDI 4,076 3,252
  1. aNumber of unique CDI episodes spaced at least 12 weeks apart
  2. Rx = non-topical metronidazole or oral vancomycin therapy