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Table 1 Cytokine production by splenocytes of immunized Kunming mice after stimulation with toxoplasma lysate antigena

From: Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice

Group Cytokine production (pg/ml)  
IFN-γ IL-2 IL-4 IL-10 IL-12 (p70)
CDPK6 + ROP18 + PLG 2092.66 ± 363.69*** 238.48 ± 6.37*** >0* 360.61 ± 296.21 4.55 ± 2.91
CDPK6 + ROP18 + 206 1727.43 ± 506.06** 257.92 ± 4.04*** >0* 520.98 ± 91.89*** <0
CDPK6 + ROP18 1835.37 ± 384.89** 251.35 ± 5.51*** >0* 409.57 ± 337.62 <0
ROP18 + PLG 1720.61 ± 329.18** 243.76 ± 91.02** >0* 56.92 ± 57.09*** 9.17 ± 15.2
ROP18 + 206 1595.37 ± 1204.87 263.7 ± 30.02*** >0* 430.08 ± 623.13 <0
ROP18 1530.8 ± 724.92* 244.52 ± 1.82*** >0* 484.58 ± 453.58 <0
CDPK6 + PLG 1040.08 ± 477.05 179.65 ± 107.16 >0* 139.41 ± 141.62 >0
CDPK6 + 206 1013.52 ± 630.91 215.95 ± 43.12*** >0* 121.55 ± 103.54 <0
CDPK6 838.58 ± 186.37 85.66 ± 140.77 >0* >0 <0
PBS + PLG 471.15 ± 232.97 45.11 ± 46.95 9.29 ± 3.56 609.99 ± 267.23 6.12 ± 7.25
PBS + 206 611.01 ± 308.16 38.89 ± 35.46 13.09 ± 4.67 613.01 ± 154.41 1.09 ± 2.26
PBS 515.27 ± 363.03 20.76 ± 32.26 14.73 ± 2.46 597.48 ± 216.81 <0
Control 590.3 ± 257.92 33.9 ± 13.16 12.43 ± 12.92 606.35 ± 376.32 <0
  1. a Splenocytes from mice were harvested 6 weeks after the last immunization
  2. The 4 control groups, PBS + PLG, PBS + 206, PBS, and blank control, were treated as controls in regard to statistical analysis. *P < 0.05. **P < 0.01. ***P < 0.001 compared with the average of the controls