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Table 1 Cytokine production by splenocytes of immunized Kunming mice after stimulation with toxoplasma lysate antigena

From: Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice

Group

Cytokine production (pg/ml)

 

IFN-Îł

IL-2

IL-4

IL-10

IL-12 (p70)

CDPK6 + ROP18 + PLG

2092.66 ± 363.69***

238.48 ± 6.37***

>0*

360.61 ± 296.21

4.55 ± 2.91

CDPK6 + ROP18 + 206

1727.43 ± 506.06**

257.92 ± 4.04***

>0*

520.98 ± 91.89***

<0

CDPK6 + ROP18

1835.37 ± 384.89**

251.35 ± 5.51***

>0*

409.57 ± 337.62

<0

ROP18 + PLG

1720.61 ± 329.18**

243.76 ± 91.02**

>0*

56.92 ± 57.09***

9.17 ± 15.2

ROP18 + 206

1595.37 ± 1204.87

263.7 ± 30.02***

>0*

430.08 ± 623.13

<0

ROP18

1530.8 ± 724.92*

244.52 ± 1.82***

>0*

484.58 ± 453.58

<0

CDPK6 + PLG

1040.08 ± 477.05

179.65 ± 107.16

>0*

139.41 ± 141.62

>0

CDPK6 + 206

1013.52 ± 630.91

215.95 ± 43.12***

>0*

121.55 ± 103.54

<0

CDPK6

838.58 ± 186.37

85.66 ± 140.77

>0*

>0

<0

PBS + PLG

471.15 ± 232.97

45.11 ± 46.95

9.29 ± 3.56

609.99 ± 267.23

6.12 ± 7.25

PBS + 206

611.01 ± 308.16

38.89 ± 35.46

13.09 ± 4.67

613.01 ± 154.41

1.09 ± 2.26

PBS

515.27 ± 363.03

20.76 ± 32.26

14.73 ± 2.46

597.48 ± 216.81

<0

Control

590.3 ± 257.92

33.9 ± 13.16

12.43 ± 12.92

606.35 ± 376.32

<0

  1. a Splenocytes from mice were harvested 6 weeks after the last immunization
  2. The 4 control groups, PBS + PLG, PBS + 206, PBS, and blank control, were treated as controls in regard to statistical analysis. *P < 0.05. **P < 0.01. ***P < 0.001 compared with the average of the controls
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BMC Infectious Diseases

ISSN: 1471-2334

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