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Table 2 Analysis of pairs of killing curves for M. tuberculosis Uganda II vs. Beijing, and M. tuberculosis Uganda II vs. Delhi/CAS

From: Mycobacterium tuberculosis Uganda II is more susceptible to rifampicin and isoniazid compared to Beijing and Delhi/CAS families

  

1x MIC (Ug-0.5 μg/ml, Be-0.03 μg/ml, Ce-0.03 μg/ml)

2x MIC (Ug-1 μg/ml, Be-0.06 μg/ml, Ce-0.24 μg/ml)

5x MIC (Ug-0.25 μg/ml, Be-0.15 μg/ml, Ce-0.15 μg/ml)

Drug (condition)

Strain

p-value, mean of diffs (95 % CI)

p-value, mean of diffs (95 % CI)

p-value, mean of diffs (95 % CI)

INH (aerobic)

Ug vs Be

0.30, −0.191 (−0.623–0.241)

0.40, −0.034 (−0.133–0.635)

0.33, −0.176 (−0.602–0.250)

Ug vs Ce

0.09, 0.809 (−0.187–1.806)

0.14, 0.408 (−0.199–1.016)

0.30, 0.103 (− 0.128–0.334)

INH (O2 depletion)

Ug vs Be

0.13, −0.023 (−0.057–0.010)

0.17, 0.053 (−0.032–0.138)

0.02, 0.094 (0.019–0.169)*

Ug vs Ce

0.20, 0.025 (−0.018–0.069)

0.14, 0.408 (−0.199–1.016)

0.55, 0.027 (−0.083–0.137)

  

1x MIC (Ug-1 μg/ml, Be-0.121 μg/ml, Ce-0.12 μg/ml)

2x MIC (Ug-2 μg/ml, Be-0.24 μg/ml, Ce-0.24 μg/ml)

5x MIC (Ug-5 μg/ml, Be-0.6 μg/ml, Ce-0.6 μg/ml)

RIF (aerobic)

Ug vs Be

0.93, 0.006 (−0.162–0.174)

0.12, −0.427 (1.025–0.169)

0.60, −0.603 (−0.603–0.391)

Ug vs Ce

0.34, −0.176 (−0.617–0.263)

0.07, 0.485 (−0.081–1.052)

0.49, 0.140 (−0.348–0.629)

RIF (O2 depletion)

Ug vs Be

0.51, −0.040 (−0.187–0.107)

0.36, 0.011 (−0.018–0.041)

0.004, −2.137 (−3.277–0.996)*

Ug vs Ce

0.13, 0.073 (−0.033–0.179)

0.01, 0.036 (0.009–0.063)*

0.005, 2.230 (0.997–3.463)*

  1. MIC, minimum inhibitory concentration; Ug, Uganda II; Ce, Delhi/CAS; Be, Beijing
  2. INH, Isoniazid; RIF, Rifampicin;
  3. *P-value <0.05