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Table 2 Analysis of pairs of killing curves for M. tuberculosis Uganda II vs. Beijing, and M. tuberculosis Uganda II vs. Delhi/CAS

From: Mycobacterium tuberculosis Uganda II is more susceptible to rifampicin and isoniazid compared to Beijing and Delhi/CAS families

   1x MIC (Ug-0.5 μg/ml, Be-0.03 μg/ml, Ce-0.03 μg/ml) 2x MIC (Ug-1 μg/ml, Be-0.06 μg/ml, Ce-0.24 μg/ml) 5x MIC (Ug-0.25 μg/ml, Be-0.15 μg/ml, Ce-0.15 μg/ml)
Drug (condition) Strain p-value, mean of diffs (95 % CI) p-value, mean of diffs (95 % CI) p-value, mean of diffs (95 % CI)
INH (aerobic) Ug vs Be 0.30, −0.191 (−0.623–0.241) 0.40, −0.034 (−0.133–0.635) 0.33, −0.176 (−0.602–0.250)
Ug vs Ce 0.09, 0.809 (−0.187–1.806) 0.14, 0.408 (−0.199–1.016) 0.30, 0.103 (− 0.128–0.334)
INH (O2 depletion) Ug vs Be 0.13, −0.023 (−0.057–0.010) 0.17, 0.053 (−0.032–0.138) 0.02, 0.094 (0.019–0.169)*
Ug vs Ce 0.20, 0.025 (−0.018–0.069) 0.14, 0.408 (−0.199–1.016) 0.55, 0.027 (−0.083–0.137)
   1x MIC (Ug-1 μg/ml, Be-0.121 μg/ml, Ce-0.12 μg/ml) 2x MIC (Ug-2 μg/ml, Be-0.24 μg/ml, Ce-0.24 μg/ml) 5x MIC (Ug-5 μg/ml, Be-0.6 μg/ml, Ce-0.6 μg/ml)
RIF (aerobic) Ug vs Be 0.93, 0.006 (−0.162–0.174) 0.12, −0.427 (1.025–0.169) 0.60, −0.603 (−0.603–0.391)
Ug vs Ce 0.34, −0.176 (−0.617–0.263) 0.07, 0.485 (−0.081–1.052) 0.49, 0.140 (−0.348–0.629)
RIF (O2 depletion) Ug vs Be 0.51, −0.040 (−0.187–0.107) 0.36, 0.011 (−0.018–0.041) 0.004, −2.137 (−3.277–0.996)*
Ug vs Ce 0.13, 0.073 (−0.033–0.179) 0.01, 0.036 (0.009–0.063)* 0.005, 2.230 (0.997–3.463)*
  1. MIC, minimum inhibitory concentration; Ug, Uganda II; Ce, Delhi/CAS; Be, Beijing
  2. INH, Isoniazid; RIF, Rifampicin;
  3. *P-value <0.05