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Table 5 Results of Meta-Analyses in Aerobic Exerciser and HIV Systematic Review: Strength Outcomes

From: Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

Outcomes

Sub-Group Comparison of Meta-Analysis

# of Individual Studies Included in Meta-Analysis

Number of Participants Included in Meta-Analysis

Weighted Mean Difference (WMD)

95 % Confidence Interval

P value of overall effect

I2 statistic (p value for heterogeneity)

Interpretation

Chest Press (1-RM)

Combined aerobic and PRE group compared with no exercise

2 studies

(Fitch 2012; [31], Tiozzo 2011 [26])

44

11.86 kg 1-RMb

2.37, 21.36

0.01a

46 %

(p = 0.18)

Significant (and potential clinically important) improvement in change in chest press 1-repetition maximum among exercisers compared with non-exercisers.

Knee Flexion (1-RM)

Combined aerobic and PRE group compared with no exercise

3 studies

(Dolan 2006 [51], Fitch 2012 [31]; Grinspoon 2000 [42])

81

10.46 kg 1-RMb

1.64, 19.29

0.02a

91 %

(p < 0.00001)

Significant (and potential clinically important) improvement in change in knee flexion 1-repetition maximum among exercisers compared with non-exercisers

Leg Press

(1-RM)

Combined aerobic and PRE group compared with no exercise

2 studies

(Fitch 2012; [31], Tiozzo 2011 [26])

44

50.96 kg 1-RMb

−13.01, 114.92

0.12

88 %

(p = 0.004)

Non-significant trend towards an increase in leg press 1-RM among exercisers compared with non-exercisers.

Knee Extension

(1-RM)

Combined aerobic and PRE group compared with no exercise

3 studies

(Dolan 2006 [51]; Fitch 2012 [31]; Grinspoon 2000 [42])

81

20.58 kg 1-RMb

−4.69, 45.86

0.11

95 %

(p < 0.00001)

Non-significant trend towards an increase in knee extension 1-RM among exercisers compared with non-exercisers.

Upper Extremity Muscle Groups

(1-RM)

Aerobic versus PRE

2 studies

(Lindegaard 2008 [30]; Lox 1995 [38])

41

14.56 kg 1-RM or 3-RMb

10.63, 18.49

<0.00001a

32 %

(p = 0.23)

Significantly (and potential clinically important) greater increase in strength among participants in the PRE group compared with the aerobic group.

Lower Extremity Muscle Groups

(1-RM)

Aerobic versus PRE

2 studies

(Lindegaard 2008 [30]; Lox 1995 [38])

41

23.09 kg 1-RM or 3-RMb

13.01, 33.18

<0.00001a

75 %

(p = 0.04)

Significantly (and potential clinically important) greater increase in strength among participants in the PRE group compared with the aerobic group.

  1. 1-RM 1 repetition maximum, 3-RM 3 repetitions maximum, PRE progressive resistive exercise
  2. aindicates statistical significance
  3. bindicates potential clinically important change in outcome