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Table 3 Pharmacokinetic non-compartmental results of isoniazid in children above and below 4 years of age

From: Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

Isoniazid <4 years old >4 years old % difference
Number of patients enrolled 64 36  
Body Weight (median kg - range) 9.0 (4.0–15.0) 19.0 (13.5–43.0)  
Age (median months - range) 12 (2–48) 96 (48–180)  
Dosage (mean - % CV) 25.0 (12.8) 27.3 (9.17) p-value: 0.0002a
CMAX (ug/mL) 4.38 5.11 −14.3
TMAX (hr) 2 3 −33.3
CL/F (L/hr) 2.48 3.88 −36.1
CL/F/BW (L/hr/kg) 0.28 0.2 40
V/F (L) 11.3 14.9 −23.8
V/F/BW (L/kg) 1.26 0.78 61.5
T1/2 (hr) 3.17 2.66 19.2
AUC0-∞ (hr × ug/mL) 20.2 25.8 −21.8
AUC0-∞/dosage (hr × ug/mL/(mg/kg)) 4.48 5.26 −14.8
T > MIC (hr) 14.2 14.5 −1.8
T > MIC/24 h (%) 59.3 60.3 −1.79
AUC0–24 h > MIC (hr × ug/mL) 16.3 22 −25.8
  1. Apart for dosage with mean and % CV, all values are reported as median (range) or as median estimates for pharmacokinetic parameters. C MAX maximum observed plasma concentration after oral administration, T MAX observed time to reach CMAX, CL/F oral elimination clearance, CL/F/BW elimination clearance corrected by the median body weight, V/F apparent volume of distribution, V/F/BW apparent volume of distribution corrected by the median body weight, T 1/2 terminal elimination half-life, AUC 0-∞ predicted area under the plasma concentration-time curve after the last dose from zero time to infinity, T > MIC time above the minimum inhibitory concentration, T > MIC/24 h percentage of the time above the minimum inhibitory concentration over the 24 h dose interval, AUC > MIC observed area under the plasma concentration-time curve above the minimum inhibitory concentration. % difference is calculated with the > 4 years group used as the reference. aMann–Whitney T-test