Skip to main content

Table 1 Baseline characteristics and outcomes of studied children

From: Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

  <4 years olda >4 years oldb Total
Number of patients enrolled, n 64 36 100
Male/Female, n (male %) 36/65 (56.3) 20/36 (55.6) 56.0
Age (months) 12 (2–48) 96 (48–180) 36 (2–180)
Body weight (kg) 9.0 (4.0–15.0) 19.0 (13.5–43.0) 10.9 (4.0–43.0)
BMI (kg/m2) 15.4 (11.9–22.0) 13.3 (10.6–20.2) 14.3 (10.6–22.0)
Malnourished, n (%) 18/64 (28.1) 20/36 (55.5) 38.0
Body weight gained (kg)    
 after 1 month 0.5 (−0.3–2.5) 0.75 (−7.5–6.0) 0.5 (−7.5–6.0)
 after 3 months 1.3 (−0.8–5.3) 2.0 (−9.0–12.5) 1.5 (−9.0–12.5)
Fast/Slow acetylator status, n (%)c 35/23 (60 %) 29/5 (85 %) 64/28 (70 %)
HIV positive, n (%)d 2/61 (3.3 %) 2/35 (5.7 %) 4/96 (4.2 %)
TBM Grade I, n (%) 43/67 (64 %) 16/33 (48 %) 59/100 (59 %)
TBM Grade II, n (%) 12/67 (18 %) 11/33 (33 %) 23/100 (23 %)
TBM Grade III, n (%) 12/67 (18 %) 6/33 (18 %) 18/100 (18 %)
TB diagnosis: Definite, n (%) 3/64 (4.7 %) 3/36 (8.3 %) 6/100 (6.0 %)
TB diagnosis: Probable, n (%) 39/64 (61 %) 27/36 (75 %) 66/100 (66 %)
TB diagnosis: Possible, n (%) 22/64 (34 %) 6/36 (17 %) 28/100 (28 %)
Death, n (%) 10/64 (16 %) 5/36 (14 %) 15/100 (15 %)
Permanent Sequelae, n (%)e 19/51 (37 %) 8/30 (27 %) 27/81 (33 %)
  1. All values are reported as median (range) unless otherwise specified. adisease severity grade assessed in children below 5 years old by Blantyre Coma Score; bdisease severity grade assessed in children over 5 years old by Glasgow Coma Score; c8 patients did not complete the NAT2 genotype; d4 patients out of 100 did not complete HIV testing; esurviving patients were assessed after treatment completion at month 8 (4 were lost to follow-up)