Fig. 4From: Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitisPlasma (open circles) and CSF (grey squares) concentration-time profiles for rifampicin stratified for age (<4 years old [left] and > 4 years old [right]). Continuous lines represent the median plasma concentration and broken lines represent the plasma upper and lower quartiles. Black stars represent plasma samples with concentrations below LOQ. Sub-therapeutic threshold: 8 μg/mL; Minimum Inhibitory Concentration (MIC): 1.0 μg/mL; Limit of Quantification (LOQ): 0.1 μg/mLBack to article page