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Table 5 Generation of antigens

From: The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis

  Antigen Sensitivity (95 % CI) Specificity (95 % CI)
Erythema migrans Whole cell 0.515 (0.328 to 0.699) 0.957 (0.899 to 0.983)
Purified 0.579 (0.466 to 0.685) 0.950 (0.895 to 0.977)
Recombinant 0.551 (0.330 to 0.753) 0.947 (0.881 to 0.977)
Neuroborreliosis Whole cell 0.723 (0.555 to 0.845) 0.904 (0.792 to 0.959)
Purified 0.756 (0.614 to 0.858) 0.963 (0.935 to 0.979)
Recombinant 0.837 (0.647 to 0.935) 0.931 (0.881 to 0.960)
Lyme arthritis* Whole cell or Purified 0.952 (0.892 to 0.979) 0.958 (0.879 to 0.986)
Recombinant 0.954 (0.862 to 0.985) 0.927 (0.886 to 0.954)
Unspecified Lyme borreliosis Whole cell 0.703 (0.563 to 0.813) 0.950 (0.863 to 0.983)
Purified 0.836 (0.463 to 0.968) 0.965 (0.855 to 0.992)
Recombinant 0.464 (0.251 to 0.692) 0.918 (0.806 to 0.968)
  1. For ACA there were insufficient data to analyse the effect of antigen used, so ACA is not in the table. 95 % CI = 95 % confidence interval. *Insufficient data to analyse whole cell assays and purified antigen assays separately