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Table 4 Summary estimates of sensitivity and specificity for IgM versus IgG versus IGM or IgG (IgT)

From: The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis

   IgM IgG IgT
  Estimate (95 % CI) Estimate (95 % CI) Estimate (95 % CI)
Erythema migrans Sensitivity 0.426 (0.361 to 0.494) 0.359 (0.293 to 0.431) 0.606 (0.503 to 0.700)
Specifcitiy 0.953 (0.924 to 0.971) 0.961 (0.939 to 0.975) 0.919 (0.885 to 0.944)
Neuroborreliosis Sensitivity 0.600 (0.526 to 0.669) 0.589 (0.515 to 0.659) 0.865 (0.812 to 0.906)
Specifcitiy 0.949 (0.924 to 0.966) 0.956 (0.935 to 0.971) 0.913 (0.869 to 0.942)
Lyme arthritis Sensitivity 0.392 (0.279 to 0.517) 0.941 (0.857 to 0.977) 0.945 (0.842 to 0.982)
Specifcitiy 0.951 (0.881 to 0.980) 0.969 (0.942 to 0.983) 0.921 (0.837 to 0.964)
Acrodermatitis Chronica Atrophicans Sensitivity 0.184 (0.090 to 0.340) 0.987 (0.821 to 0.999) 0.978 (0.874 to 0.996)
Specifcitiy 0.965 (0.930 to 0.983) 0.966 (0.952 to 0.976) 0.932 (0.883 to 0.962)
Unspecified Lyme borreliosis* Sensitivity 0.596 (0.324 to 0.820) 0.557 (0.448 to 0.661) 0.792 (0.960 to 0.867)
Specifcitiy 0.911 (0.818 to 0.959) 0.986 (0.877 to 0.998) 0.947 (0.725 to 0.992)
  1. IgT refers to assays measuring IgM and IgG simultaneously. 95 % CI = 95 % confidence interval. *Analyses were not possible for healthy controls; these are the estimates for studies including cross-reacting controls