Fig. 3

Raw ROC plots and fitted summary ROC curves. Every symbol reflects a 2 × 2 table, one for each test. Blue triangle = commercial EIA; Red diamond = in house EIA; Green rectangle = commercial IB; Black circle = in house IB. One study may have contributed more than one 2 × 2 table. The dots on the summary ROC curves reflect the summary estimate of sensitivity and specificity. a neuroborreliosis case-control studies including healthy controls. b: neuroborreliosis cross-sectional studies. c unspecified Lyme borreliosis case-control studies including healthy controls. d unspecified Lyme borreliosis cross-sectional studies. The size of the symbol reflects the sample size. For the cross-sectional studies, only the overall summary ROC curve is shown, while for the case-control designs the curves are shown for the different test-types