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Table 1 Characteristics of included studies

From: Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis

Author, Year Journal Country Study design Age (years, m = months) Sample size
- TB cases
- Controls
TB diagnostic test Sensitivity Specificity TST cut-off (mm) TB burden
Detjen et al. (2007) [27] Clin Infect Dis. Germany cohort study 4 m-15 28
22
TST 1a 1a >10 Low
QFT-IT 0.93a 1a
T-SPOT.TB 0.93a 1a
Domínguez et al. (2008) [28] Clin Vaccine Immunol. Spain cohort study ≤18 9 TST 1a ≥5 Low
QFT-IT 0.67a
T-SPOT.TB 0.86a
Kampmann et al. (2009) [29] Eur Respir J. United Kingdom cohort study 3 m-16 25 TST 0.88 ≥10 Low
QFT-IT 0.80
T-SPOT.TB 0.58
Lighter et al. (2009) [30] Int J Tuberc Lung Dis. USA cohort study ≤17 7
21
TST 0.86a 0.86a ≥10 Low
QFT-IT 0.86a 1a
Hansted et al. (2009) [31] BMC Pulm Med. Lithuania cohort study 10–17 23
52
TST 1 0.35a ≥10 High
T-SPOT.TB 1 0.90a
Bamford et al. (2010) [32] Arch Dis Child. United Kingdom cross-sectional study 7.2 m-16 49 TST 0.82 >15 Low
T-SPOT.TB 0.67
QFT-IT 0.78
Sun Lin et al. (2010) [33] Chinese Medical Journal China case–control study ≤18 18
51
TST 0.61 0.71 ≥10 High
T-SPOT.TB 0.83 0.94
Tsolia et al. (2010) [34] Pediatr Infect Dis J. Greece cohort study ≤15 13 TST 0.85 ≥5 Low
QFT-IT 0.85a
Cruz et al. (2011) [35] Pediatrics. USA cohort study ≤18 13 TST 0.77 ≥5 Low
T-SPOT.TB 0.92
Chiappini et al. (2012) [36] PLoS One. Italy cohort study ≤18 5
29
TST 0.80a 0.97a ≥5 Low
QFT-IT 0a 1a
Lodha et al. (2013) [37] Int J Tuberc Lung Dis. India RCT 6 m - 15 128 TST 0.90a ≥10 High
QFT-IT 0.83a
Blandinières et al. (2013) [38] J Infect. France case–control study ≤15 24 TST 0.78a ≥10 Low
QFT-IT 0.70a
Jenum et al. (2014) [39] Pediatr Infect Dis J. India cohort study 9 m -28 m 4
692
TST 0.75a 0.91a ≥10 High
QFT-IT 0.75a 0.95a
Chiappini et al. (2014) [40] Pediatr Infect Dis J. Italy cohort study <18 28
210
TST 0.96a Low
QFT-IT 0.89a 0.96a
T-SPOT.TB 0.78a 0.99a
Petrone et al. (2015) [41] Biomed Res Int. Uganda cohort study 1 m - 16 7 TST 0.50a ≥10 High
QFT-IT 0.60a
  1. a Sensitivity and specificity were not directly reported and were calculated from available data in the study
  2. RCT randomized controlled trial