Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis

Laurenti, Patrizia; Raponi, Matteo; de Waure, Chiara; Marino, Marta; Ricciardi, Walter; Damiani, Gianfranco

doi:10.1186/s12879-016-1461-y

Table 1 Characteristics of included studies

From: Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis

Author, Year	Journal	Country	Study design	Age (years, m = months)	Sample size - TB cases - Controls	TB diagnostic test	Sensitivity	Specificity	TST cut-off (mm)	TB burden
Detjen et al. (2007) [27]	Clin Infect Dis.	Germany	cohort study	4 m-15	28 22	TST	1^a	1^a	>10	Low
						QFT-IT	0.93^a	1^a
						T-SPOT.TB	0.93^a	1^a
Domínguez et al. (2008) [28]	Clin Vaccine Immunol.	Spain	cohort study	≤18	9	TST	1^a	–	≥5	Low
						QFT-IT	0.67^a	–
						T-SPOT.TB	0.86^a	–
Kampmann et al. (2009) [29]	Eur Respir J.	United Kingdom	cohort study	3 m-16	25	TST	0.88	–	≥10	Low
						QFT-IT	0.80	–
						T-SPOT.TB	0.58	–
Lighter et al. (2009) [30]	Int J Tuberc Lung Dis.	USA	cohort study	≤17	7 21	TST	0.86^a	0.86^a	≥10	Low
Lighter et al. (2009) [30]	Int J Tuberc Lung Dis.	USA	cohort study	≤17	7 21	QFT-IT	0.86^a	1^a	≥10	Low
Hansted et al. (2009) [31]	BMC Pulm Med.	Lithuania	cohort study	10–17	23 52	TST	1	0.35^a	≥10	High
Hansted et al. (2009) [31]	BMC Pulm Med.	Lithuania	cohort study	10–17	23 52	T-SPOT.TB	1	0.90^a	≥10	High
Bamford et al. (2010) [32]	Arch Dis Child.	United Kingdom	cross-sectional study	7.2 m-16	49	TST	0.82	–	>15	Low
						T-SPOT.TB	0.67	–
						QFT-IT	0.78	–
Sun Lin et al. (2010) [33]	Chinese Medical Journal	China	case–control study	≤18	18 51	TST	0.61	0.71	≥10	High
Sun Lin et al. (2010) [33]	Chinese Medical Journal	China	case–control study	≤18	18 51	T-SPOT.TB	0.83	0.94	≥10	High
Tsolia et al. (2010) [34]	Pediatr Infect Dis J.	Greece	cohort study	≤15	13	TST	0.85	–	≥5	Low
Tsolia et al. (2010) [34]	Pediatr Infect Dis J.	Greece	cohort study	≤15	13	QFT-IT	0.85^a	–	≥5	Low
Cruz et al. (2011) [35]	Pediatrics.	USA	cohort study	≤18	13	TST	0.77	–	≥5	Low
Cruz et al. (2011) [35]	Pediatrics.	USA	cohort study	≤18	13	T-SPOT.TB	0.92	–	≥5	Low
Chiappini et al. (2012) [36]	PLoS One.	Italy	cohort study	≤18	5 29	TST	0.80^a	0.97^a	≥5	Low
Chiappini et al. (2012) [36]	PLoS One.	Italy	cohort study	≤18	5 29	QFT-IT	0^a	1^a	≥5	Low
Lodha et al. (2013) [37]	Int J Tuberc Lung Dis.	India	RCT	6 m - 15	128	TST	0.90^a	–	≥10	High
Lodha et al. (2013) [37]	Int J Tuberc Lung Dis.	India	RCT	6 m - 15	128	QFT-IT	0.83^a	–	≥10	High
Blandinières et al. (2013) [38]	J Infect.	France	case–control study	≤15	24	TST	0.78^a	–	≥10	Low
Blandinières et al. (2013) [38]	J Infect.	France	case–control study	≤15	24	QFT-IT	0.70^a	–	≥10	Low
Jenum et al. (2014) [39]	Pediatr Infect Dis J.	India	cohort study	9 m -28 m	4 692	TST	0.75^a	0.91^a	≥10	High
Jenum et al. (2014) [39]	Pediatr Infect Dis J.	India	cohort study	9 m -28 m	4 692	QFT-IT	0.75^a	0.95^a	≥10	High
Chiappini et al. (2014) [40]	Pediatr Infect Dis J.	Italy	cohort study	<18	28 210	TST	0.96^a	–	–	Low
						QFT-IT	0.89^a	0.96^a
						T-SPOT.TB	0.78^a	0.99^a
Petrone et al. (2015) [41]	Biomed Res Int.	Uganda	cohort study	1 m - 16	7	TST	0.50^a	–	≥10	High
Petrone et al. (2015) [41]	Biomed Res Int.	Uganda	cohort study	1 m - 16	7	QFT-IT	0.60^a	–	≥10	High

^a Sensitivity and specificity were not directly reported and were calculated from available data in the study
RCT randomized controlled trial

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