TY - JOUR AU - Glezen, W. P. AU - Taber, L. H. AU - Frank, A. L. AU - Kasel, J. A. PY - 1986 DA - 1986// TI - Risk of primary infection and reinfection with respiratory syncytial virus JO - Arch Pediatr Adolesc Med VL - 140 UR - https://doi.org/10.1001/archpedi.1986.02140200053026 DO - 10.1001/archpedi.1986.02140200053026 ID - Glezen1986 ER - TY - STD TI - Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360(6):588–98. ID - ref2 ER - TY - STD TI - Brand HK, de Groot R, Galama J, Brouwer ML, Teuwen K, Hermans PW, Melchers WJ, Warris A. Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis. Pediatr Pulmonol. 2012;47(4):393–400. ID - ref3 ER - TY - JOUR AU - Simoes, E. A. PY - 2003 DA - 2003// TI - Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease JO - J Pediatr VL - 143 UR - https://doi.org/10.1067/S0022-3476(03)00511-0 DO - 10.1067/S0022-3476(03)00511-0 ID - Simoes2003 ER - TY - JOUR AU - Wang, E. E. AU - Law, B. J. AU - Stephens, D. PY - 1995 DA - 1995// TI - Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection JO - J Pediatr VL - 126 UR - https://doi.org/10.1016/S0022-3476(95)70547-3 DO - 10.1016/S0022-3476(95)70547-3 ID - Wang1995 ER - TY - JOUR AU - Hooper, L. V. AU - Littman, D. R. AU - Macpherson, A. J. PY - 2012 DA - 2012// TI - Interactions between the microbiota and the immune system JO - Science VL - 336 UR - https://doi.org/10.1126/science.1223490 DO - 10.1126/science.1223490 ID - Hooper2012 ER - TY - JOUR AU - Lee, Y. K. AU - Mazmanian, S. K. PY - 2010 DA - 2010// TI - Has the microbiota played a critical role in the evolution of the adaptive immune system? JO - Science VL - 330 UR - https://doi.org/10.1126/science.1195568 DO - 10.1126/science.1195568 ID - Lee2010 ER - TY - JOUR AU - Vissers, M. AU - Groot, R. AU - Ferwerda, G. PY - 2014 DA - 2014// TI - Severe viral respiratory infections: are bugs bugging? JO - Mucosal Immunol VL - 7 UR - https://doi.org/10.1038/mi.2013.93 DO - 10.1038/mi.2013.93 ID - Vissers2014 ER - TY - JOUR AU - Avadhanula, V. AU - Wang, Y. AU - Portner, A. AU - Adderson, E. PY - 2007 DA - 2007// TI - Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein JO - J Med Microbiol VL - 56 UR - https://doi.org/10.1099/jmm.0.47086-0 DO - 10.1099/jmm.0.47086-0 ID - Avadhanula2007 ER - TY - JOUR AU - Yokota, S. AU - Okabayashi, T. AU - Hirakawa, S. AU - Tsutsumi, H. AU - Himi, T. AU - Fujii, N. PY - 2012 DA - 2012// TI - Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line JO - Mediators Inflamm VL - 2012 UR - https://doi.org/10.1155/2012/528568 DO - 10.1155/2012/528568 ID - Yokota2012 ER - TY - JOUR AU - Hament, J. M. AU - Kimpen, J. L. AU - Fleer, A. AU - Wolfs, T. F. PY - 1999 DA - 1999// TI - Respiratory viral infection predisposing for bacterial disease: a concise review JO - FEMS Immunol Med Microbiol VL - 26 UR - https://doi.org/10.1111/j.1574-695X.1999.tb01389.x DO - 10.1111/j.1574-695X.1999.tb01389.x ID - Hament1999 ER - TY - STD TI - Hament J-M, Aerts PC, Fleer A, van Dijk H, Harmsen T, Kimpen JL, Wolfs TF. Enhanced adherence of Streptococcus pneumoniae to human epithelial cells infected with respiratory syncytial virus. Pediatr Res. 2004;55(6):972–8. ID - ref12 ER - TY - STD TI - Smith CM, Sandrini S, Datta S, Freestone P, Shafeeq S, Radhakrishnan P, Williams G, Glenn SM, Kuipers OP, Hirst RA. Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. Am J Respir Crit Care Med. 2014;190(2):196–207. ID - ref13 ER - TY - STD TI - Nguyen DT, Louwen R, Elberse K, van Amerongen G, Yuksel S, Luijendijk A, Osterhaus AD, Duprex WP, de Swart RL. Streptococcus pneumoniae Enhances Human Respiratory Syncytial Virus Infection In Vitro and In Vivo. PLoS One. 2015;10(5):e0127098. ID - ref14 ER - TY - JOUR AU - Madhi, S. A. AU - Klugman, K. P. AU - Group, T. V. T. PY - 2004 DA - 2004// TI - A role for Streptococcus pneumoniae in virus-associated pneumonia JO - Nat Med VL - 10 UR - https://doi.org/10.1038/nm1077 DO - 10.1038/nm1077 ID - Madhi2004 ER - TY - STD TI - Short KR, Vissers M, de Kleijn S, Zomer A, Kedzierska K, Grant E, Reading P, Hermans P, Ferwerda G, Diavatopoulos D. Bacterial lipopolysaccharide inhibits influenza virus infection of human macrophages and the consequent induction of CD8+ T cell immunity. J Innate Immun. 2013;6(2):129–39. ID - ref16 ER - TY - STD TI - Nguyen DT, De Witte L, Ludlow M, Yüksel S, Wiesmüller K-H, Geijtenbeek TB, Osterhaus AD, de Swart RL. The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation. PLoS Pathog. 2010;6(8):e1001049. ID - ref17 ER - TY - JOUR AU - Wang, J. H. AU - Kwon, H. -. J. AU - Lee, B. -. J. AU - Jang, Y. J. PY - 2007 DA - 2007// TI - Staphylococcal enterotoxins A and B enhance rhinovirus replication in A549 cells JO - Am J Rhinol VL - 21 UR - https://doi.org/10.2500/ajr.2007.21.3101 DO - 10.2500/ajr.2007.21.3101 ID - Wang2007 ER - TY - STD TI - Vissers M, Remijn T, Oosting M, de Jong DJ, Diavatopoulos DA, Hermans PW, Ferwerda G. Respiratory syncytial virus infection augments NOD2 signaling in an IFN‐β‐dependent manner in human primary cells. Eur J Immunol. 2012;42(10):2727–35. ID - ref19 ER - TY - STD TI - Sajjan US, Jia Y, Newcomb DC, Bentley JK, Lukacs NW, LiPuma JJ, Hershenson MB. H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression. FASEB J. 2006;20(12):2121–3. ID - ref20 ER - TY - STD TI - Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci. 2011;108(13):5354–9. ID - ref21 ER - TY - STD TI - Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012;37(1):158–70. ID - ref22 ER - TY - STD TI - Kong MY, Clancy JP, Peng N, Li Y, Szul TJ, Xu X, Oster R, Sullender W, Ambalavanan N, Blalock JE. Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus. Eur Respir J. 2014;43(4):1086–96. ID - ref23 ER - TY - JOUR AU - Brand, K. H. AU - Ahout, I. M. AU - Groot, R. AU - Warris, A. AU - Ferwerda, G. AU - Hermans, P. W. PY - 2012 DA - 2012// TI - Use of MMP‐8 and MMP‐9 to assess disease severity in children with viral lower respiratory tract infections JO - J Med Virol VL - 84 UR - https://doi.org/10.1002/jmv.23301 DO - 10.1002/jmv.23301 ID - Brand2012 ER - TY - STD TI - Brand HK, Ferwerda G, Preijers F, de Groot R, Neeleman C, Staal FJ, Warris A, Hermans PW. CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. Pediatr Res. 2012;73(2):187–93. ID - ref25 ER - TY - JOUR AU - Vissers, M. AU - Hartman, Y. AU - Groh, L. AU - Jong, D. J. AU - Jonge, M. I. AU - Ferwerda, G. PY - 2014 DA - 2014// TI - Recognition of Streptococcus pneumoniae and Muramyl Dipeptide by NOD2 Results in Potent Induction of MMP-9, Which Can Be Controlled by Lipopolysaccharide Stimulation JO - Infect Immun VL - 82 UR - https://doi.org/10.1128/IAI.02150-14 DO - 10.1128/IAI.02150-14 ID - Vissers2014 ER - TY - STD TI - Hong J-S, Greenlee KJ, Pitchumani R, Lee S-H, Song L-z, Shan M, Chang SH, Park PW, Dong C, Werb Z. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. J Immunol. 2011;186(11):6427–36. ID - ref27 ER - TY - JOUR AU - Poll, T. AU - Keogh, C. V. AU - Guirao, X. AU - Buurman, W. A. AU - Kopf, M. AU - Lowry, S. F. PY - 1997 DA - 1997// TI - Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia JO - J Infect Dis VL - 176 UR - https://doi.org/10.1086/514062 DO - 10.1086/514062 ID - Poll1997 ER - TY - JOUR AU - Templeton, K. E. AU - Scheltinga, S. A. AU - Beersma, M. F. AU - Kroes, A. C. AU - Claas, E. C. PY - 2004 DA - 2004// TI - Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 JO - J Clin Microbiol VL - 42 UR - https://doi.org/10.1128/JCM.42.4.1564-1569.2004 DO - 10.1128/JCM.42.4.1564-1569.2004 ID - Templeton2004 ER - TY - STD TI - Shak JR, Cremers AJ, Gritzfeld JF, de Jonge MI, Hermans PW, Vidal JE, Klugman KP, Gordon SB. Impact of Experimental Human Pneumococcal Carriage on Nasopharyngeal Bacterial Densities in Healthy Adults. PLoS One. 2014;9(6):e98829. ID - ref30 ER - TY - STD TI - Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001;293(5529):498–506. ID - ref31 ER - TY - JOUR AU - Nizet, V. AU - Colina, K. F. AU - Almquist, J. R. AU - Rubens, C. E. AU - Smith, A. L. PY - 1996 DA - 1996// TI - A virulent nonencapsulated Haemophilus influenzae JO - J Infect Dis VL - 173 UR - https://doi.org/10.1093/infdis/173.1.180 DO - 10.1093/infdis/173.1.180 ID - Nizet1996 ER - TY - JOUR AU - Gritzfeld, J. F. AU - Gordon, S. B. AU - Cremers, A. PY - 2013 DA - 2013// TI - Detection limits in pneumococcal carriage JO - Pediatr Infect Dis J VL - 32 UR - https://doi.org/10.1097/INF.0b013e31827add5f DO - 10.1097/INF.0b013e31827add5f ID - Gritzfeld2013 ER - TY - JOUR AU - Gritzfeld, J. AU - Cremers, A. AU - Ferwerda, G. AU - Ferreira, D. M. AU - Kadioglu, A. AU - Hermans, P. W. AU - Gordon, S. B. PY - 2014 DA - 2014// TI - Density and duration of experimental human pneumococcal carriage JO - Clin Microbiol Infect VL - 20 UR - https://doi.org/10.1111/1469-0691.12752 DO - 10.1111/1469-0691.12752 ID - Gritzfeld2014 ER - TY - STD TI - Chien Y-W, Vidal JE, Grijalva CG, Bozio C, Edwards KM, Williams JV, Griffin MR, Verastegui H, Hartinger SM, Gil AI. Density interactions between Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in the nasopharynx of young Peruvian children. Pediatr Infect Dis J. 2013;32(1):72. ID - ref35 ER - TY - STD TI - Suarez-Arrabal MC, Mella C, Lopez SM, Brown NV, Hall MW, Hammond S, Shiels W, Groner J, Marcon M, Ramilo O, et al. Nasopharyngeal bacterial burden and antibiotics: Influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis. J Infect. 2015;71(4):458–69. ID - ref36 ER - TY - JOUR AU - Dagan, R. AU - Sikuler-Cohen, M. AU - Zamir, O. AU - Janco, J. AU - Givon-Lavi, N. AU - Fraser, D. PY - 2001 DA - 2001// TI - Effect of a conjugate pneumococcal vaccine on the occurrence of respiratory infections and antibiotic use in day-care center attendees JO - Pediatr Infect Dis J VL - 20 UR - https://doi.org/10.1097/00006454-200110000-00008 DO - 10.1097/00006454-200110000-00008 ID - Dagan2001 ER - TY - JOUR AU - Chappell, K. AU - Brealey, J. AU - Mackay, I. AU - Bletchly, C. AU - Hugenholtz, P. PY - 2013 DA - 2013// TI - Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children JO - J Med Microbiol Diagnosis S VL - 1 ID - Chappell2013 ER - TY - JOUR AU - Delclaux, C. AU - Delacourt, C. AU - d’Ortho, M. -. P. AU - Boyer, V. AU - Lafuma, C. AU - Harf, A. PY - 1996 DA - 1996// TI - Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane JO - Am J Respir Cell Mol Biol VL - 14 UR - https://doi.org/10.1165/ajrcmb.14.3.8845180 DO - 10.1165/ajrcmb.14.3.8845180 ID - Delclaux1996 ER - TY - STD TI - Yeo S-J, Yun Y-J, Lyu M-A, Woo S-Y, Woo E-R, Kim S-J, Lee H-J, Park H-K, Kook Y-H. Respiratory syncytial virus infection induces matrix metalloproteinase-9 expression in epithelial cells. Arch Virol. 2002;147(2):229–42. ID - ref40 ER - TY - JOUR AU - DeVincenzo, J. P. AU - Saleeby, C. M. AU - Bush, A. J. PY - 2005 DA - 2005// TI - Respiratory syncytial virus load predicts disease severity in previously healthy infants JO - J Infect Dis VL - 191 UR - https://doi.org/10.1086/430008 DO - 10.1086/430008 ID - DeVincenzo2005 ER - TY - STD TI - Fodha I, Vabret A, Ghedira L, Seboui H, Chouchane S, Dewar J, Gueddiche N, Trabelsi A, Boujaafar N, Freymuth F. Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity. J Med Virol. 2007;79(12):1951–8. ID - ref42 ER - TY - STD TI - Wright PF, Gruber WC, Peters M, Reed G, Zhu Y, Robinson F, Coleman-Dockery S, Graham BS. Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J Infect Dis. 2002;185(8):1011–8. ID - ref43 ER - TY - JOUR AU - DeVincenzo, J. P. AU - Buckingham, S. C. PY - 2002 DA - 2002// TI - Relationship between respiratory syncytial virus load and illness severity in children JO - J Infect Dis VL - 186 UR - https://doi.org/10.1086/344331 DO - 10.1086/344331 ID - DeVincenzo2002 ER - TY - JOUR AU - McConnochie, K. M. AU - Roghmann, K. J. PY - 1986 DA - 1986// TI - Parental smoking, presence of older siblings, and family history of asthma increase risk of bronchiolitis JO - Am J Dis Child VL - 140 ID - McConnochie1986 ER -