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Table 1 Associations between reproductive health and vaginal hygiene factors and the 1-year period prevalence of HPV infection by phylogenetic group in the Ludwig-McGill cohort study

From: Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study

Variable

Subgenus 1a (n = 108)

Subgenus 2a (n = 495)

Subgenus 3a (n = 131)

ORb

95 % CI

ORb

95 % CI

ORb

95 % CI

Reproductive Health Factors

 Condom Use

  Former vs. Never

1.28

0.79, 2.07

0.90

0.71, 1.15

2.00

1.23, 3.24

  Current vs. Never

1.43

0.83, 2.48

1.09

0.82, 1.45

2.00

1.15, 3.47

 Oral Contraceptives

   < 6 years vs. Never

1.25

0.66, 1.38

0.98

0.71, 1.35

1.40

0.83, 2.37

  6+ years vs. Never

1.23

0.60, 2.53

1.00

0.70, 1.43

0.62

0.32, 1.19

 Intrauterine Device

  Yes vs. No

0.48

0.30, 0.75

0.78

0.62, 0.98

0.73

0.49, 1.08

 Tubal Sterilization

  Yes vs. No

1.24

0.65, 1.36

0.84

0.59, 1.21

0.65

0.33, 1.30

 Contraceptive Injection

  Yes vs. No

1.96

1.22, 3.16

1.34

1.00, 1.79

1.34

0.83, 2.17

 Natural Products

  Yes vs. No

-

-

0.37

0.13, 1.05

0.74

0.17, 3.20

 Vaginal Products

  Yes vs. No

-

-

0.82

0.37, 1.81

0.32

0.04, 2.40

Genital Health and Hygiene Factors

 Menstrual Cloth

  Yes vs. No

0.54

0.32, 0.91

0.93

0.74, 1.18

1.02

0.68, 1.53

 Hygienic Tampon

  Yes vs. No

1.49

0.87, 2.54

1.33

0.98, 1.81

1.30

0.79, 2.14

 Douching

  Frequent vs. Infrequent

1.20

0.53, 2.69

1.29

0.83, 2.00

0.11

0.02, 0.81

 Douching Products

  Natural vs. None

0.96

0.60, 1.54

0.92

0.72, 1.17

0.90

0.57, 1.41

  Medical vs. None

1.09

0.23, 5.15

0.97

0.46, 2.06

2.75

0.98, 7.73

  Unknown vs. None

1.18

0.27, 5.22

0.51

0.21, 1.21

2.92

1.20, 7.12

 Genital Discomfort

  Yes vs. No

0.96

0.64, 1.45

0.96

0.78, 1.20

0.89

0.60, 1.31

 Recent Discomfort

  Yes vs. No

0.99

0.65, 1.50

1.11

0.89, 1.38

1.22

0.84, 1.75

 Pain or Bleeding

  Yes vs. No

2.83

0.59, 13.51

1.14

0.34, 3.75

0.91

0.12, 7.00

Gynecologic Products

 Antibiotic

  Former vs. Never

3.86

0.86, 17.34

0.83

0.51, 1.33

1.43

0.52, 3.97

  Current vs. Never

5.95

1.14, 30.97

0.97

0.53, 1.79

1.84

0.56, 6.02

 Antifungal

  Former vs. Never

5.14

1.17, 22.52

1.10

0.70, 1.75

1.85

0.68, 5.02

  Current vs. Never

1.64

0.22, 12.24

1.06

0.56, 2.02

1.74

0.49, 6.11

 Abrasion

  Former vs. Never

-

-

1.68

0.40, 7.72

-

-

  Current vs. Never

-

-

1.10

0.08, 16.23

-

-

 External Products

  Former vs. Never

0.75

0.20, 2.84

-

-

-

-

  Current vs. Never

1.36

0.48, 3.89

-

-

-

-

 Unknown Products

  Former vs. Never

2.82

0.64, 12.42

0.96

0.62, 1.49

2.21

0.81, 6.01

  Current vs. Never

3.44

0.63, 18.68

1.10

0.60, 2.03

2.82

0.83, 9.53

 Home-made Products

  Natural vs. None

1.22

0.78, 1.92

0.91

0.72, 1.15

0.98

0.66, 1.47

  Medical vs. None

0.80

0.27, 2.40

1.26

0.77, 2.04

0.76

0.29, 2.02

  Unknown vs. None

2.75

0.53, 14.15

1.33

0.45, 3.91

5.33

1.80, 15.82

Vaginal Health Characteristics

 Cervical Ectropion

  Yes vs. No

0.37

0.05, 2.77

0.89

0.42, 1.91

0.74

0.17, 3.10

 Gynecologic Surgery

  Yes vs. No

2.05

1.11, 3.79

0.90

0.60, 1.37

0.89

0.42, 1.89

 Gynecologic Treatment/Infection

  Yes vs. No

1.73

1.13, 2.65

1.17

0.92, 1.50

1.26

0.83, 1.89

 Previous Gynecologic Infection

  HPV vs. None

3.87

2.09, 7.14

2.02

1.27, 3.19

1.21

0.54, 2.71

  Non-HPV vs. None

1.33

0.81, 2.19

1.03

0.78, 1.34

1.27

0.82, 1.97

Cytology Observations

 Bacterial Infection

  Yes vs. No

1.28

0.63, 2.63

1.30

0.88, 1.91

1.31

0.68, 2.52

 Fungal Infection

  Yes vs. No

1.25

0.61, 2.54

1.29

0.88, 1.87

1.48

0.83, 2.66

 General Inflammation

  Yes vs. No

2.10

1.37, 3.22

1.53

1.21, 1.94

1.12

0.74, 1.69

  1. a Subgenus 1 (HPVs-6, 11, 32, 40, 42, 44, 54 and 55), Subgenus 2 (HPVs-16, 18, 26 31, 33–35, 39, 45, 51–53, 56, 58, 59, 66–70, 73 and 82) and Subgenus 3 (HPVs-57, 61, 62, 71, 72, 81, 83, 84 and 89) infections were determined based on the phylogenetic classification of HPV types
  2. b Odds ratios were adjusted for age, lifetime number of sexual partners and empirical confounders (identified using a 5 % change in estimate strategy) such as race, marital status, education, age at first intercourse, age at menarche, number of pregnancies, smoking, alcohol drinking and years since last Pap smear