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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis

Fig. 3

Th1 cytokine secretion levels. IFNγ (P = 0.0021) a, TNFα (P < 0.0001) b, and IL-12 (P = 0.0185) c produced 72 h after stimulating splenocytes ex vivo with recombinant Sm-cathepsin B. Splenocytes were isolated from every C57BL/6 mice belonging to each group: Saline control (saline), Montanide ISA 70VG control (Montanide), and Sm-cathepsin B in the presence of Montanide ISA 720 VG (SmCB + Montanide). Cytokine production was analyzed by QUANSYS multiplex ELISA. Geometric means and 95 % confidence intervals are shown. (ns = not significant, * P < 0.05, ** P < 0.01, *** P < 0.001)

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