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BMC Infectious Diseases

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Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

  • Thomas Jaenisch1,
  • Dong Thi Hoai Tam2, 3,
  • Nguyen Tan Thanh Kieu2,
  • Tran Van Ngoc4,
  • Nguyen Tran Nam5,
  • Nguyen Van Kinh6,
  • Sophie Yacoub2, 7,
  • Ngoun Chanpheaktra8,
  • Varun Kumar8, 24,
  • Lucy Lum Chai See9,
  • Jameela Sathar10,
  • Ernesto Pleités Sandoval11,
  • Gabriela Maria Marón Alfaro11, 25,
  • Ida Safitri Laksono12,
  • Yodi Mahendradhata12,
  • Malabika Sarker13,
  • Firoz Ahmed14,
  • Andrea Caprara15,
  • Bruno Souza Benevides15,
  • Ernesto T. A. Marques16,
  • Tereza Magalhaes16,
  • Patricia Brasil17,
  • Marco Netto18,
  • Adriana Tami19, 20,
  • Sarah E. Bethencourt20,
  • Maria Guzman21,
  • Cameron Simmons2, 22,
  • Nguyen Thanh Ha Quyen2,
  • Laura Merson2, 23,
  • Nguyen Thi Phuong Dung2,
  • Dorothea Beck1,
  • Marius Wirths1,
  • Marcel Wolbers2, 23,
  • Phung Khanh Lam2,
  • Kerstin Rosenberger1 and
  • Bridget Wills2, 23Email author
BMC Infectious DiseasesBMC series – open, inclusive and trusted201616:120

Received: 2 February 2016

Accepted: 18 February 2016

Published: 11 March 2016

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
2 Feb 2016 Submitted Original manuscript
Author responded Author comments
Resubmission - Version 2
Submitted Manuscript version 2
18 Feb 2016 Editorially accepted
11 Mar 2016 Article published 10.1186/s12879-016-1440-3

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

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Authors’ Affiliations

Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Children’s Hospital Number 2, Ho Chi Minh City, Vietnam
National Hospital for Tropical Diseases, Hanoi, Vietnam
Department of Medicine, Imperial College, London, UK
Angkor Hospital for Children, Siem Reap, Cambodia
University of Malaya Medical Centre, Kuala Lumpur, Malaysia
Ampang Hospital, Kuala Lumpur, Malaysia
Hospital Nacional de Niños Benjamin Bloom, San Salvador, El Salvador
Gadjah Mada University, Yogyakarta, Indonesia
James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh
International Center for Diarrhoeal Diseases Research, Dhaka, Bangladesh
Universidade Estadual Do Ceará, Fortaleza, Brazil
Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, Brazil
Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
Secretaria Municipal de Saúde de Resende, Rio de Janeiro, Brazil
Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela
Institute Pedro Kouri, Havana, Cuba
Department of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Australia
Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK
Present address: Rwanda Military Hospital and the University of Rwanda in Kigali, Kigali, Rwanda
Present address: St. Jude Children’s Research Hospital, Memphis, USA