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Table 4 Parameters recorded in the study case report form

From: SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): an observational pharmacokinetic study in critically ill patients

Admission details
• Patient characteristics (identification number, age, sex)
• Inclusion and exclusion criteria
• Consent details
• Co-enrolment
• Date of hospital admission
• Patient’s height and weight
• Admission diagnosis
• Date of ICU admission
• APACHE II score on ICU admission
Clinical details
• Site of infection
• Identification of pathogen(s) and susceptibility to study antibiotic
• SOFA score (ICU admission, and sampling occasions 1 and 2)
• Cumulative fluid balance
• Medication details (antibiotic(s), dose administered, dosing intervals)
• Clinical response
Renal Replacement Therapy
• Modality
• Filter membrane size
• Filter membrane material
• Transmembrane pressure
• Replacement fluid flow rate (pre/post dilution)
• Dialysate fluid flow rate
• Targeted hourly fluid removal rate
Laboratory Investigations
• Blood sampling time
• Measured effluent volume at pre-defined collection time
• Effluent sampling time
• Residual measured urinary creatinine clearance
• Residual urine sampling time
• Haematocrit
• Liver function tests
Completion and outcome details
• Reason for discontinuation/withdrawal
• Reason for protocol deviation/violation
• Adverse events
• Vital status at ICU and hospital discharge
• 28 day survival
 
  1. Abbreviations: ICU Intensive care unit, APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment Score
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