Table 1 Inclusion and exclusion criteria

Inclusion criteria

• Age 18 years or older

• AKI requiring RRT (defined according to RIFLE^a, AKIN^b or KDIGO^c criteria)

• Expected to require RRT for at least 4 days with two (2) sampling sechedules

• Clinical indication for IV piperacillin-tazobactam, meropenem, imipenem-cilastatin, vancomycin or linezolid

• Presence of intra-arterial line for blood sampling if RRT filter port sampling not possible

• Informed consent from patient or patient’s authorised representative

Exclusion criteria

• Imminent death/patient not expected to survive

• Major bleeding or blood haemoglobin concentration <70 g/L or platelets <20 x 10⁹/L

• Regular dosing with any of the 5 study antibiotics for greater than 36 h, within the 7 days prior to enrolment

• Unable to obtain consent