Table 3 Serious adverse events (SAE) occurring in 6 patients under daptomycin-based antimicrobial therapy
Patient | Dose (mg/kg/d) | Additional antibiotic | SAE | SAE onset (days) | Cmin at SAE onset (mg/L) | Daptomycin withdrawal | Companion drug withdrawal |
|---|---|---|---|---|---|---|---|
1 | 8,8 | Rifampicin* | Neutropenia | 73 | NA | Yes | Yes |
2 | 7,1 | Rifampicin | Hypereosinophilia | 92 | NA | Yes | No |
3 | 8,4 | Rifampicin | Eosinophilic pneumonia, rhabdomyolysis | 10 | 134 | Yes | Yes |
4 | 8,7 | Pristinamycin | PICC thrombosis | 12 | NA | Yes | No |
5 | 8,7 | None | Eosinophilic pneumonia | 23 | 38 | Yes | NA |
6 | 7,8 | Linezolid | Acute renal failure | 8 | NA | Yes | Yes |