Table 2 Adverse events potentially related to the daptomycin-based antimicrobial therapy (n = 43) that occurred in 17 of the 43 included patients. Daptomycin dose is expressed in mg/kg/d. AEs onsets are notified in days
Adverse events | n (%) | Daptomycin dose (mean, range) | AE onset (mean, range) | Daptomycin withdrawal | Companion drug withdrawal |
|---|---|---|---|---|---|
Hematologic disorders | 12 (28) | 7,8 (7–9) | 44 (7–92) | 4/12 | 3/12 |
Hypereosinophilia | 6 (14) | 7,8 (7–9) | 43 (10–92) | 3/6 | 1/6 |
Neutropenia | 4 (9) | 7,8 (7–9) | 73 (49–88) | 1/4 | 2/4 |
Increased blood CPK | 4 (9) | 7,5 (7–8) | 49 (9–92) | 2/4 | 2/4 |
PICC thrombosis | 3 (7) | 8,3 (7–9) | 39 (12–79) | 1/3 | 0/3 |
Hepatic disorders | 3 (7) | 8,2 (7,5–9) | 71 (13–112) | 0/3 | 1/3 |
Eosinophilic pneumonia | 2 (5) | 8,5 (8–9) | 17 (6–23) | 2/2 | 1/1 |
Increased blood creatinine | 1 (2) | 8 | 8 | 1 | 1 |
Pancreatitis | 1 (2) | 8 | 180 | 0 | 1 |