Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya

BMC Infectious Diseases

Table 4 Prevalence of HBsAg and BCP/PC mutations observed among HBV genotype A and D sequences

	Mutation (%)^a
Nucleotide mutation	Genotype A	Genotype D
HBsAg amino acid substitutions^b	11/77 (14)	0
BCP/PC insertion/deletions^c	5/70 (7)	0
C1653T	2/70 (3)	3/9 (33)
A1752C	0	1/9 (11)
T1753V	3/70 (4)	2/9 (22)
A1762T/G1764A^d	23/70 (33)	4/9 (44)
G1809T	65/70 (93)	0
A1811T/C	7/70 (10)	0
C1812T	62/70 (89)	0
C1858T	4/70 (6)	9/9 (100)
G1862T/C	24/70 (34)	0
G1888A	47/70 (67)	0
G1896A	3/70 (4)	4/9 (44)

^aGenotype A: 77 and 70 samples could be amplified for HBsAg and BCP/PC sequences, respectively; Genotype D: Sequence was available in both regions for all 9 samples. ^bThe following substitutions within the antigenic determinant region (amino acids 100–160) of the HBsAg gene were observed: M103I, L109P, I110L, G112R, T114S, T115A, T118K, Q129R, G130N, M133I, F134I/V, P135H, T143M, S155R; ^csee text; ^dincludes A1762/A1764 (6 genotype A and 2 genotype D) and T1762/G1764 (3 genotype A)

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