| Overall | Any first trimester exposure to LPV/r | Earliest LPV/r exposure in second/third trimester |
---|---|---|---|
Total live births (singleton + multiple), n | 4609 | 1116 | 3403 |
ᅟLive births with ≥1 abnormality, n (%) | 134a (2.9) | 32 (2.9) | 97 (2.9) |
ᅟᅟ95 % CI | 2.4–3.4 | 1.9–3.8 | 2.3–3.4 |
Stillbirths, n | 36 | 8 | 27 |
ᅟStillbirths with ≥1 abnormality, n (%) | 6 (16.7) | 1 (12.5) | 5 (18.5) |
ᅟᅟ95 % CI | 3.9–29.5 | – | 2.9–34.2 |
Category of abnormality | |||
á…ŸCNS | 8 | 3 | 5 |
á…ŸEye, ear, face and neckb | 4 | 0 | 4 |
á…ŸCleft lip and/or palate | 2 | 1 | 1 |
á…ŸObstructive heart defects, right | 2 | 0 | 2 |
á…ŸObstructive heart defects, left | 1 | 0 | 1 |
ᅟHeart—other defects | 13 | 6 | 6 |
á…ŸRespiratory systemc | 3 | 1 | 2 |
á…ŸLower gastrointestinal system | 8 | 2 | 6 |
á…ŸFemale genitalia | 1 | 1 | 0 |
á…ŸMale genitaliad | 6 | 1 | 5 |
á…ŸRenal and urinary systemc | 13 | 2 | 10 |
á…ŸLimb reduction/additione | 31 | 5 | 25 |
á…ŸOther musculoskeletal defects | 15 | 3 | 12 |
á…ŸSkin and skin derivativesf | 8 | 2 | 5 |
á…ŸChromosome anomaly | 15 | 4 | 11 |
á…ŸOther organ systems-specified | 4 | 1 | 3 |
á…ŸSpecified syndromes | 3 | 1 | 1 |
á…ŸUnspecified abnormality | 3 | 0 | 3 |