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Table 4 Stratified MTCT rates in singleton pregnanciesa

From: Maternal and foetal outcomes among 4118 women with HIV infection treated with lopinavir/ritonavir during pregnancy: analysis of population-based surveillance data from the national study of HIV in pregnancy and childhood in the United Kingdom and Ireland

 

2003–2007

2008–2012

 

n/N

% (95 % CI)

n/N

% (95 % CI)

Overall MTCT rate

18/1633

1.1 (0.6–1.6)

12/2406

0.5 (0.2–0.8)

á…ŸBy timing of LPV/r initiation

á…Ÿá…ŸBefore conception

2/333

0.6 (0.2–2.2)

2/635

0.3 (0.1–1.1)

á…Ÿá…ŸFirst trimester

0/33

–

0/77

–

á…Ÿá…ŸSecond trimester

8/858

0.9 (0.5–1.8)

5/1397

0.4 (0.2–0.8)

á…Ÿá…ŸThird trimester

8/376

2.1 (1.1–4.1)

5/264

1.9 (0.8–4.4)

á…ŸBy baseline CD4+ T-cell count

á…Ÿá…Ÿ<200 cells/mm3

3/157

1.9 (0.7–5.5)

2/206

1.0 (0.3–3.5)

ᅟᅟ200–349 cells/mm3

4/340

1.2 (0.5–3.0)

1/506

0.2 (0.04–1.1)

ᅟᅟ≥350 cells/mm3

4/600

0.7 (0.3–1.7)

2/1171

0.2 (0.1–0.6)

á…Ÿá…ŸMissing CD4+ T-cell count

7/536

1.3 (0.6–2.7)

7/523

1.3 (0.6–2.7)

  1. Abbreviations: MTCT mother-to-child transmission, CI confidence interval, LPV/r lopinavir/ritonavir
  2. aReported for the 4609 pregnancies where infant HIV status was available