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Table 5 Multivariate model examining association between HIV infection and time to death among patients treated for tuberculosis*

From: Impact of HIV on mortality among patients treated for tuberculosis in Lima, Peru: a prospective cohort study

Characteristic Multivariate model Direct effect model
(without mediators) (with mediators)
N = 1699, 136 deaths N = 1658, 127 deaths
Adjusted HR Adjusted HR
  (95 % CI) P value (95 % CI) P value
HIV positive 6.06 (3.969.27) <0.001 4.67 (2.997.29) <0.001
Pediatric casea 0.64 (0.15–2.64) 0.536 0.45 (0.11–1.90) 0.276
Female gender 0.92 (0.61–1.37) 0.670 0.96 (0.63–1.47) 0.870
Unemployed 2.24 (1.553.25) <0.001 1.82 (1.242.65) 0.002
Baseline sputum AFB smear positive 1.91 (1.103.31) 0.021 1.88 (1.073.29) 0.028
Able to perform ADLs    0.26 (0.170.41) <0.001
Low BMIb    1.71 (1.182.48) 0.004
Dyspnea    1.56 (1.042.34) 0.030
  1. ADLs activities of daily living, AFB acid-fast bacilli, BMI body mass index, CI confidence interval, HIV human immunodeficiency virus, HR hazard ratio
  2. *Boldface indicates P < 0.05. The total n for each multivariate model is lower than the analysis cohort (n = 1701) because of complete case drop of observations with missing data
  3. aDefined as age <15 years
  4. bDefined as BMI <20 kg/m2 in men, BMI <18.5 kg/m2 in women