Table 5 Multivariate model examining association between HIV infection and time to death among patients treated for tuberculosis*
Characteristic | Multivariate model | Direct effect model | ||
|---|---|---|---|---|
(without mediators) | (with mediators) | |||
N = 1699, 136 deaths | N = 1658, 127 deaths | |||
Adjusted HR | Adjusted HR | |||
(95 % CI) | P value | (95 % CI) | P value | |
HIV positive | 6.06 (3.96–9.27) | <0.001 | 4.67 (2.99–7.29) | <0.001 |
Pediatric casea | 0.64 (0.15–2.64) | 0.536 | 0.45 (0.11–1.90) | 0.276 |
Female gender | 0.92 (0.61–1.37) | 0.670 | 0.96 (0.63–1.47) | 0.870 |
Unemployed | 2.24 (1.55–3.25) | <0.001 | 1.82 (1.24–2.65) | 0.002 |
Baseline sputum AFB smear positive | 1.91 (1.10–3.31) | 0.021 | 1.88 (1.07–3.29) | 0.028 |
Able to perform ADLs | 0.26 (0.17–0.41) | <0.001 | ||
Low BMIb | 1.71 (1.18–2.48) | 0.004 | ||
Dyspnea | 1.56 (1.04–2.34) | 0.030 | ||